The M1 antigens associated with gastric fucomucins, oncofetal markers of the distal colonic mucosa, were demonstrated to be more closely associated with adenomas [92 of 139 (66%)] than with invasive adenocarcinomas [27 of 218 (12%)]. They were always expressed in tumors containing the M3 antigen normally associated with the intestinal mucus. The M1 antigens, present in 100% of hyperplastic poly...

As a part of a program directed toward the elucidation of the role of viruses in mouse and human breast cancer, a variety of immunological techniques were applied to a study of the humoral immune response of mice and of humans to their breast tumors. Tumor-bearing mice were found to produce antibodies against a complex array of tumor cell-associated antigens, including mouse mammary tumor virus...

Background: Hydatid disease is characterized by long-term growth of hydatid cysts in the human. The glycan antigens have an important role in the immunology of hydatid cyst. In this study immunological reaction of host sera to different glycan antigens of the cyst, has been investigated. Methods: The antibody responses were tested to glycoprotein and glycolipid of the laminated layer (LL), c...

Chronic lymphocytic leukemia (CLL) is associated with a variety of immunologic disturbances. Hypogammaglobulinemia and autoimmune phenomena are both often present in this disease. In contrast, humoral or cellular antitumor responses are rarely observed. It has been previously shown that antigens detected in patients with malignant diseases can provide information regarding intracellular molecul...

Abstract Glioblastomas are immunologically “cold” tumors with intense immunosuppressive myeloid cell- and sparse cytotoxic T-cell infiltration. Therefore, viral vector vaccines may be a promising approach to boost the induction of glioblastoma-targeted T cells. It has been previously shown that heterologous prime-boost vaccination chimpanzee-derived adenovirus ChAdOx1 modified vaccinia Ankara (...

ABO blood type antigens are polymorphic, inherited structures presented on the surface of red blood cells. Although ABO blood group antigens is the most important antigens in transfusion medicine, its main role is not clearly clarified. Correlation between ABO blood group and susceptibility to certain infectious and non-infectious diseases is a controversial issue. Since, lack of blood type ant...

Tumor cells were treated with rabbit antibody to tumor-associated cell surface antigens and tested with erythrocytes coated with antibody specific for the sensitizing rabbit immunoglobulin. The sensitized tumor cells formed rosettes with the indicator cells. By this method, we confirmed that line 1 and line 10 hepatoma cells (from two tumors independently induced by diethylnitrosamine in strain...

Autoimmune diseases frequently occur in females, and a parallel sexually dimorphic suffering is observed individuals who suffer chronic pain. Though perception environment influence the chronicity of pain, this review illustrates examples specific, evolutionarily preserved, physiological parameters that may be responsible differentially contribute to pain affect treatment outcomes females males...

The ongoing development of novel personalized cancer therapies has resulted in the implementation T cells enriched with synthetic chimeric antigen receptors, known as receptors cell (CAR-T) cells, into clinical practice. CAR-T are able to recognize and bind specific antigens present on surface target — so-called tumor-associated antigens. This innovative method been approved for treatment hemat...

The development of cancer vaccines is based on the premise that tumor cells are potentially targetable by host immunity through effective presentation tumor-associated antigens to reactive T-cell populations. Vaccine efficacy may be limited functional properties effector including lack high-affinity T target self-antigens. In contrast, neoantigens arise from tumor-specific mutational events gen...