Summary Massively parallel sequencing is now widely used, but data interpretation is only as good as the reference assembly to which it is aligned. While the number of reference assemblies has rapidly expanded, most of these remain at intermediate stages of completion, either as scaffold builds, or as chromosome builds (consisting of correctly ordered, but not necessarily correctly oriented sca...

A model is proposed showing how automatically extracted and manually written association rules can be used to build the structure of a narrative from real-life temporal data. The generated text’s communicative goal is to help the reader construct a causal representation of the events. A connecting associative thread allows the reader to follow associations from the beginning to the end of the t...

Circadian clocks are auto-regulatory loops in which 'clock' gene products feedback to regulate their own expression. This explains how they keep oscillating, but how do they first get going? It appears that the transcription factor dClock not only drives the oscillation within the fruit fly's clock, but also plays a pivotal role in pre-assembling the clockwork.

Component based design is a new paradigm to build distributed systems and applications. The problem of compositional verification of such systems is however still open. We investigate methods and concepts for the provision of “sound” assemblies. We define a behavioural interface type language endowed with a (decidable) set of interface compatibilty and subtyping rules. We define an abstract, dy...

Bionanotechnology seeks to modify and design new biopolymers and their applications and uses biological systems as cell factories for the production of nanomaterials. Molecular self-assembly as the main organizing principle of biological systems is also the driving force for the assembly of artificial bionanomaterials. Protein domains and peptides are particularly attractive as building blocks ...

We show that graphene nano-sheets, when appropriately functionalised, can form self-assembling nanocontainers which may be opened or closed using a chemical trigger such as pH or polarity of solvent. Conceptual design rules are presented for different container structures, whose ability to form and encapsulate guest molecules is verified by molecular dynamics simulations. The structural simplic...

A human operator assembles components using his skill and judgement which is difficult to incorporate in a mechanized device. Though the mechanized system will offer higher speed and reliability, but its inherent inaccuracies will limit the success in assembling. Thus, it is essential that these inaccuracies are determined to establish its ‘Process capability’ , and also provide information for...