In order to understand the potential controls on Asian tectonics during the subduction of the Tethys and Indian lithospheres, we reconstruct the coupled subduction-continent deformation history using tomographic imaging, kinematics constraints and numerical modeling. The global P-waves tomographic images of the mantle below the India-Asia collision zone provide constraints on the deep structure...

Genetic variants in multiple cellular pathways have been associated with an altered risk of oesophageal cancer. In this study, eight genes previously associated with an altered risk of oesophageal squamous cell carcinoma (OSCC) in European or Asian populations were investigated in two South African populations. We genotyped 12 single-nucleotide polymorphisms and one insertion/deletion variant i...

Microarray single-nucleotide polymorphism genotyping, combined with imputation of untyped variants, has been widely adopted as an efficient means to interrogate variation across the human genome. "Genomic coverage" is the total proportion of genomic variation captured by an array, either by direct observation or through an indirect means such as linkage disequilibrium or imputation. We have per...

OBJECTIVE Mexico's current population structure has been defined by admixture between European, Native American, and to some extent African, groups that started in the sixteenth century. The aim of this research was to analyze the relative contributions of these continental population groups to the seven regions of the state of Guerrero, Mexico. METHODS A total of 104 ancestry informative mar...

The sequencing of the human genome (2003) has been followed by a number technical developments that allow detailed characterization (including complete sequencing) DNA thousands individuals. This provided an estimate genetic diversity: approx. 3 million base substitutions within our includes 3,000 bases. Although divergence between any two individuals is small, it responsible for much phenotypi...

The sequencing of the human genome (2003) has been followed by a number technical developments that allow detailed characterization (including complete sequencing) DNA thousands individuals. This provided an estimate genetic diversity: approx. 3 million base substitutions within our includes 3,000 bases. Although divergence between any two individuals is small, it responsible for much phenotypi...

We used cladistic analysis of chloroplast gene sequences (ndhF and rpl16) to test biogeographic hypotheses in the woody genus Gleditsia. Previous morphological comparisons suggested the presence of two eastern Asian-eastern North American species pairs among the 13 known species, as well as other intra- and inter-continental disjunctions. Results from phylogenetic analyses, interpreted in light...

Continuing inconsistent use of the term ‘Asian’ and its appearance for the first time in the 2001 Census justifies an examination of its utility in population and health research. Given the potential for ‘Asian’ to describe either persons with origins in the Indian subcontinent or those originating from continental Asia, there is a strong argument in studies employing ethnicity as a measure of ...

In his Kelly West Award Lecture, Narayan suggested that the pathogenesis of type 2 diabetes may be fundamentally different in high-risk populations who vary dramatically in degree of adiposity (1). For example, he raised the possibility that type 2 diabetes was due to “poor insulin secretion” in thin individuals (Asian Indians), whereas the culprit was “poor insulin action” in overweight/obese ...

Social scientists have become increasingly interested in the racial identification choices of multiracial individuals, partly as a result of the federal government’s new “check all that apply” method of racial identification. However, the majority of work to date has narrowly defined the population of multiracial individuals as the “biracial” children of single-race parents. In this article, we...