Transition metal‐free Claisen‐type condensation between two different amides was developed. N ‐phenyl‐ ‐tosylbenzamide derivatives reacted with enolizable such as ‐methyl pyrrolidinone and , ‐dimethyl acetamide in the presence of NaHMDS to give their corresponding β ‐ketoamides moderate‐to‐good yields.

In the 40 years since the inception of dynamic NMR methods, much effort has been invested to quantify and understand the barrier to rotation about the C-N bond in amides.1 Carbamates, which also exhibit the approximately planar N-CdO framework responsible for hindered rotation in amides, have received considerably less attention, although they are important biologically as anticonvulsants, loca...

Reactions of the aryl complexes Rh(aryl){? 3 -P,O,P-[xant(P i Pr 2 ) ]} (1; = 3,5-Me C 6 H (a), 5 (b), 3,5-Cl (c), 3-FC 4 (d); xant(P 9,9-dimethyl-4,5-bis-(diisopropylphosphino)xanthene) with O , CO, and MeO CC?CCO Me have been performed. Under 1 atm pentane solutions afford dinuclear peroxide derivatives [Rh(aryl){? -P,P-xant(P }] (?-O (2a–2d) as yellow solids. In solution, these species are u...

Directed C–H functionalization is a powerful means to functionalize otherwise unreactive bonds, for which aminoquinoline amides provide and frequently used directing group. Saturated N-heterocycles are crucial motifs in medicinal chemistry. However, the of has posed considerable challenges, often giving incomplete conversions. On unsymmetrical substrates, poorly understood regio- stereoselectiv...

Nitrile is a functional group that usually is transformed to amides or carboxylic acids under strong reaction conditions in acidic or basic media and high temperatures. Amides have also been prepared from nitriles at room temperature using strong oxidizing agents such as hydrogen peroxide or sodium superoxide in DMSO. On the other hand biocatalytic hydrolysis of nitriles mediated by nitrilase, ...

Amide hydrogen exchange (HX) is widely used in protein biophysics even though our ignorance about the HX mechanism makes data interpretation imprecise. Notably, the open exchange-competent conformational state has not been identified. Based on analysis of an ultralong molecular dynamics trajectory of the protein BPTI, we propose that the open (O) states for amides that exchange by subglobal flu...

This communication describes the chemoselective metal-free reduction of tertiary amides to the corresponding amines. Hantzsch ester is used as a mild reducing agent for the reduction of trifluoromethanesulfonic anhydride activated amides providing the tertiary amines with high functional group tolerance.

A direct asymmetric hydrogenation of unprotected enamino esters and amides is described. Catalyzed by Rh complexes with Josiphos-type chiral ligands, this method gives beta-amino esters and amides in high yield and high ee (93-97% ee). No acyl protection/deprotection is required.

a highly efficient procedure for the preparation of n,n'-alkylidenebisamides in the presence of bf3.sio2 as a catalyst is described. n,n'-alkylidenebisamides have been prepared via one-pot three-component condensation reaction of various aldehydes and amides. all of the reactions proceeded in high yields and in moderately short reaction times.