Background. The chronic recommendation of pediatric drugs could exhibit erosive and cariogenic problems. Objective. To evaluate the effects of different pediatric drugs on the color stability of various restorative materials. Methods. Five specimens (1 mm × 3 mm) were prepared and immersed in ten different pediatric drugs and agitated every 8 hours daily for 2 min up to 1 week. Between immersio...

Various biological factors have been implicated in convulsive seizures, involving side effects of drugs. For the preclinical safety assessment of drug development, it is difficult to predict seizure-inducing side effects. Here, we introduced a machine learning-based in vitro system designed to detect seizure-inducing side effects. We recorded local field potentials from the CA1 alveus in acute ...

Caco-2 cells are currently the most used in vitro tool for prediction of the potential oral absorption of new drugs. The existence of computational models based on this data may potentiate the early selection process of new drugs, but the current models are based on a limited number of cases or on a reduced molecular space. We present an artificial neural network based only on calculated molecu...

Previous work has shown that the discriminative stimulus effects of centrally administered isoproterenol are mediated primarily via beta1-adrenergic receptors. In the present study, this model was used to investigate the ability of antidepressant drugs displaying various pharmacological profiles to stimulate beta1-adrenergic receptors in vivo; this was assessed by determining whether they subst...

background: the challenge of antiepileptic drugs (aeds) management is to attain the best compromise between the desire to maximize seizure control and the need to keep side‑effects within tolerable limits for the individual patient. to reduce devastation in iranian epileptic patients, the aim of this study was to explore the overall outcome following aeds prescription. methods: a cross‑sectiona...

background: hip fractures are serious fall injuries that often result in long-term functional impairment and increased mortality. as the population ages, the number of hip fractures is likely to increase worldwide. the main objective of this pilot study was to evaluate the risk factors of hip fracture among the older adults in the lebanese population. methods: this pilot epidemiological, prospe...

conclusions our results showed that broad-spectrum antibiotics such as imipenem, meropenem, fosfomycin, cefoperazone/sulbactam, and vancomycin would be the first line and the most effective drugs for the empirical treatment of urinary tract pathogens due to their higher resistance rates against other drugs like cephalexin, cephradine, ciprofloxacin, levofloxacin, and norfloxacin. patients and m...

background: pediatric patients on chemotherapy are vulnerable to invasive fungal infection especially candida spices. resistance to antifungal agents has increased in candida spp., especially in non-albicans species. this study aims to assess the susceptibility of candida spp. strains isolated from children with acute leukemia less than 18 years. materials and methods: this prospective cross-se...

Shortages of prescription generic drugs have recently made headlines in Canada and elsewhere. The causes and possible solutions for these shortages are still unclear. With the failure of "market forces," has the time come to establish a Crown corporation to ensure the supply of essential drugs?