PURPOSE The purpose of this study was to compare histologic and magnetic resonance imaging (MRI) evaluation of articular cartilage regeneration in patients with chondral lesions treated by arthroscopic subchondral drilling followed by postoperative intra-articular injections of hyaluronic acid (HA) with and without peripheral blood stem cells (PBSC). METHODS Fifty patients aged 18 to 50 years...

BACKGROUND Tear conversion followed by repair and trans-tendon techniques have been widely used for partial-thickness rotator cuff tears. Both of them showed favorable results with regard to the management of articular-sided partial-thickness rotator cuff tears (PTRCTs) of more than 50% thickness. However, controversy continues with the best management. This study aims to compare the clinical o...

Articular cartilage injury and repair is an issue of growing importance. Although common, defects articular present a unique clinical challenge due to its poor self-healing capacity, which largely avascular nature. There critical need better study understand cellular healing mechanisms achieve more effective therapies for regeneration. This article aims describe the key features being modelled ...

Human and equine cell transplant strategies for cartilage lesions usually result in scar tissue that is similar to what is produced naturally during the repair process. In this study, culture-expanded de-differentiated chondrocytes and primary bone marrow stromal cells at a pre-transplantation time-point were compared along with neonatal cartilage to repair tissue. Transcriptional profiling usi...

©2005 British Editorial Society of Bone and Joint Surgery doi:10.1302/0301-620X.87B4. 15971 $2.00 J Bone Joint Surg [Br] 2005;87-B:445-9. Chondral injuries involving the knee are common. In a recent study of 993 consecutive arthroscopies scored using the International Cartilage Repair Society (ICRS) knee evaluation form, 1 articular cartilage pathology was found in 66% of patients, while 11% ha...

introduction: although, the effect of direct intra-articular injection of bone marrow stem cells (bmscs) on the repair of articular cartilage and the effect of elaeagnus angustifolia extract on pain relief in patients with osteoarthritis have been investigated, no studies has been conducted to compare the effects of these two therapeutic methods on the mechanical properties of articular cartila...

Background: Different methods of surgical treatment for acromioclavicular(AC) joint injury were considered in the literature. The purpose of the study was to compare intra-articular AC repair technique with the extra-articular coracoclavicular repair technique for the patients with Rockwood type III and VAC joint injury when indicated. Methods: Nineteen consecutive patients with Rockwood type I...

Autologous chondrocyte implantation (ACI) is a significant technique that has gained widespread use for the treatment of focal articular cartilage damage. Since its inception in 2004, the Tissue Engineering Group (TEG) of the Faculty of Medicine, University Malaya has been dedicated to carrying out extensive research on this cell-based therapy. The objective of this report, comprising one clini...

The effect of autologous platelet rich fibrin (PRF), a second generation platelet product, on the healing of experimental articular cartilage lesions was evaluated in an animal model. Full thickness cartilage lesions with a diameter of 6 mm and depth of 5 mm were created in the weight bearing area of femoral condyles of both hind limbs in 12 adult mixed breed dogs. Defects in the left hind limb...