Currently, there is an unmet therapeutic need for the medical management of cardiac arrest, as evident from high mortality rate associated with this condition. These dire outcomes can be attributed to severe nature and poor prognosis disorder. However, current treatment modalities, while helping augment survival, are limited do not offer adequate improvements outcomes. Treatment modalities part...

Abstract Truncus arteriosus (TA) with interrupted aortic arch (IAA) is a rare congenital cardiac anomaly. Traditionally, IAA would require period of deep hypothermic circulatory arrest (DHCA) for reconstruction. DHCA may cause myocardial depression and neuro-developmental dysfunction. repair presently being performed low-flow selective cerebral perfusion distal body arrest. Even though this pre...

Sindrom pasca-henti jantung merupakan keadaan kompleks dan kritis dengan mortalitas tinggi. Tatalaksana membutuhkan pendekatan multidisiplin meliputi stabilisasi status kardiopulmoner, penanganan penyebab, strategi neuroproteksi dini, pencegahan berulangnya henti jantung. Pendekatan multimodal diperlukan untuk prediksi keluaran neurologis.
 Post-cardiac arrest syndrome is complex and criti...

INTRODUCTION Therapeutic hypothermia is largely used to protect the brain following return of spontaneous circulation (ROSC) after cardiac arrest (CA), but it is unclear whether we should start therapeutic hypothermia earlier, that is, before ROSC. METHODS We performed a systematic search of PubMed, EMBASE, CINAHL, the Cochrane Library and Ovid/Medline databases using "arrest" OR "cardiac arr...

Cells arrest in the G1 or G0 phase of the cell cycle in response to a variety of negative growth signals that induce arrest by different molecular pathways. The ability of human papillomavirus (HPV) oncogenes to bypass these signals and allow cells to progress into the S phase probably contributes to the neoplastic potential of the virus. The E7 protein of HPV-16 was able to disrupt the respons...

An in vitro model of mycobacterial growth arrest was developed using Mycobacterium bovis BCG. When an exponentially growing culture was transferred to an evacuated tube, growth continued; treatment with a source of nitric oxide (diethylenetriamine-nitric oxide adduct [DETA-NO] at 50 microM) halted growth immediately, and aeration restored growth. When the period of growth arrest exceeded 4 h, a...

BACKGROUND The purpose of the present study is to improve understanding of the epidemiology of cardiac arrest in the school setting, with a special focus on the role of school-based automated external defibrillators. METHODS AND RESULTS The investigation was a retrospective study of emergency medical service-treated, nontraumatic, out-of-hospital cardiac arrests in Seattle and King County, Wa...

Irreversible translation arrest occurs in reperfused neurons that will die by delayed neuronal death. It is now recognized that suppression of protein synthesis is a general response of eukaryotic cells to exogenous stressors. Indeed, stress-induced translation arrest can be viewed as a component of cell stress responses, and consists of initiation, maintenance, and termination phases that work...

In response to DNA damage, cells arrest at specific stages in the cell cycle. This arrest must fulfill at least 3 requirements: it must be activated promptly; it must be sustained as long as damage is present to prevent loss of genomic information; and after the arrest, cells must re-enter into the appropriate cell cycle phase to ensure proper ploidy. Multiple molecular mechanisms capable of ar...