Experiments on hydrothermal degradation of Pyrococcus abyssi biomass were conducted at elevated pressure (40 MPa) over a 200-450 °C temperature range in sapphire reaction cells. Few organic compounds could be detected in the 200 °C experiment. This lack was attributed to an incomplete degradation of P. abyssi cells. On the contrary, a wide range of soluble organic molecules were generated at te...

Environmental problems have encouraged investigation of renewable energies. The organic waste treating through fast pyrolysis seems to be a highly promising option for decreasing pollutants. Olive pomace, major source in countries with high production olive oil (mainly Spain, Italy, and Greece), is clear target valorisation. Dried pomace together the ashes obtained during drying process was ble...

Pyrazinamide, the first-line antitubercular drug, has been regarded the basic component of tuberculosis treatment for over sixty years. Researchers have investigated its effect on Mycobacterium tuberculosis for this long time, and as a result, new potential targets of pyrazinamide or its active form, pyrazinoic acid, have been found. We have designed and prepared 3-(phenyl-carbamoyl)pyrazine-2-...

Excess matrix degradation is one of the hallmarks of cancer and is an important factor in the process of tumor progression. It is implicated in invasion, metastasis, growth, angiogenesis and migration. Many characteristics of matrix metalloproteinases (MMPs) make them attractive therapeutic and diagnostic targets. MMP expression is upregulated at the tumor site, with localization of activity in...

The rate of photocatalytic oxidation polystyrene over 0.1 wt% copper-doped TiO2 catalyst spin coated onto a flat substrate is investigated as function the deposition speed and, hence, film thickness. Photoinduced force microscopy and photoelectron spectroscopy show no evidence any products remaining on surface after reaction. reaction shows discernible dependence speed; it close to zero order i...

We report the synthesis and investigation into structure-property relationships of eight different low molecular weight hydrogelators based on a bisaromatic urea core unit, all which form gels as pH solution is lowered. The are functionalized with carboxylic acid moieties one aromatic ring, other ring features nitro functional group either in meta- or para-position relative to linkage. Ortho-me...

Remote amide bonds in simple N-acyl amino acid amide or peptide derivatives 1 can be surprisingly unstable hydrolytically, affording, in solution, variable amounts of 3 under mild acidic conditions, such as trifluoroacetic acid/water mixtures at room temperature. This observation has important implications for the synthesis of this class of compounds, which includes N-terminal-acylated peptides...

A practical protocol was developed that allows performing decarboxylative cross-coupling reactions in continuous flow reactors. Various biaryls were thus synthesized from aromatic carboxylic acids and aryl triflates using a Cu/Pd-catalyst system.