The effects of spatial correlations of density fluctuations on merger histories of dark matter haloes (so-called ‘merger trees’) are analysed. We compare the mass functions of dark haloes derived by a new method for calculating merger trees, that proposed by Rodrigues & Thomas (RT), with those given by other methods such as the Block model, the Press-Schechter formula and our own formula in whi...

We use a large dark matter simulation of a cold dark matter ( CDM) model to investigate the clustering and environmental dependence of the number of substructures in a halo. Focusing on redshift z = 1, we find that the halo occupation distribution is sensitive at the tens of per cent level to the surrounding density and to a lesser extent to asymmetry of the surrounding density distribution. We...

We construct mock galaxy catalogues to analyse clustering properties of a Λ cold dark matter (ΛCDM) universe within a cosmological dark matter simulation of sufficient resolution to resolve structure down to the scale of dwarfs. We show that there is a strong age-clustering correlation for objects likely to host luminous galaxies, which includes the satellite halo (subhalo) population. Older mo...

A model of the gravitationally evolved dark matter distribution, in the Eulerian space, is developed. It is a simple extension of the excursion set model that is commonly used to estimate the mass function of collapsed dark matter haloes. In addition to describing the evolution of the dark matter itself, the model allows one to describe the evolution of the Eulerian space distribution of the ha...

BACKGROUND Recombinant human erythropoietin (rHuEpo) is a definitive treatment for anaemia in chronic kidney disease (CKD). During long-term rHuEpo treatment most patients develop and show persistent iron deficiency in spite of oral iron supplementation. Abnormalities of iron absorption and transport in the duodenum may contribute to this deficiency. METHODS To investigate changes in iron abs...

We use an extremely large volume (2.4hGpc), high resolution N-body simulation to measure the higher order clustering of dark matter haloes as a function of mass and internal structure. We are able to measure clustering for haloes corresponding to rarer peaks than was possible in previous studies. We use a novel “cross-moment” countsin-cells technique which suppresses discreteness noise. This al...

We have constructed realistic, self-consistent models of triaxial elliptical galaxies embedded in triaxial dark matter haloes. We examined three different models for the shape of the dark matter halo: (i) the same axis ratios as the luminous matter (0.7:0.86:1); (ii) a more prolate shape (0.5:0.66:1); (iii) a more oblate shape (0.7:0.93:1). The models were obtained by means of the standard orbi...

We report the generation of a tetracycline-regulated (Tet ON) transgenic mouse model for acute and chronic expression of the iron regulatory peptide hepcidin in the liver. We demonstrate that short-term and long-term tetracycline-dependent activation of hepcidin in adult mice leads to hypoferremia and iron-limited erythropoiesis, respectively. This clearly establishes the key role of hepcidin i...

In the first (1) of this series of studies on the pathogenesis of the anemia of infection, it was pointed out that there must be in association with infection a derangement in the intermediate metabolism of iron. This condusion was based on the observation that in cases of infection associated with anemia, the plasma iron content is markedly lowered below the normal; this appears early, and is ...