Review of literature on the health effects of arecanut chewing shows that it is not carcinogenic in normal dose. It was reported that an adult human being masticate up to 0.5g of arecanut/kg bw/day. Animal studies have revealed that feeding of processed arecanut (dried or boiled) at 1.0g/kg body weight/day and pan masala up to 1.67g/kg bw/day were safe for mice. Arecanut paste when applied to b...

Sixty five methanolic extracts of Sumatran rainforest plants representing 63 species of 21 families were assayed in vivo for antinematodal activity against Bursaphelenchus xylophilus using our cotton ball-fungal mat method. Extracts of 27 plants species from 14 families exhibited antinematodal activity, while 37 species were inactive. Among them, three extracts of Bischofia javanica, Knema hook...

BACKGROUND Chewing betel-nuts (Areca catechu) is carcinogenic but the risk for hepatocellular carcinoma (HCC) and liver cirrhosis (LC) is little considered. Worldwide 600 million people chew betel, including emigrants from palm-growing countries. OBJECTIVE We aimed to assess the relationships and dose-response effects of betel chewing on LC and HCC risks, since habit cessation could reduce th...

This study explored the antioxidant potential and anti-fatigue effects of polyphenols extracted from Areca Catechu L. husk (AHP). Radicals scavenging activities and reducing power were determined to evaluate the antioxidant potentials in vitro and a weight loaded forced swimming test (WFST) was used to estimate the anti-fatigue effect. The main components of AHP were analyzed by HPCE at last. T...

BACKGROUND Chewing areca nut (AN), also known as betel nut, is common in Asia and the South Pacific and the habit has been linked to a number of serious health problems including oral cancer. Use of AN in pregnancy has been associated with a reduction in mean birthweight in some studies, but this association and the relationship between AN chewing and other adverse pregnancy outcomes remain poo...

The current study was aimed at investigating the effect of Areca catechu nut dichloromethane fraction (7 mg/kg) on monoamines (serotonin and dopamine) modulation (5-hydroxytryptophan-induced tremors and phenylethylamine-induced stereotypes) and its interaction with tyramine (cheese effect). The dichloromethane fraction caused pronounced increase in 5-HTP-induced tremors (50%) with negligible PE...