BACKGROUND Human papilloma virus (HPV) has been implicated in the development of a large proportion of oropharyngeal squamous cell carcinoma (OPSCC). Current techniques used to diagnose HPV etiology require histopathologic analysis. We aim to investigate the diagnostic accuracy of a new application non-histopathologic diagnostic tests to help assist diagnosis of HPV-related oropharyngeal tumors...

BACKGROUND This study validates the accuracy of the Injury Severity Score (ISS) and the New Injury Severity Score (NISS) systems for prediction of need intubatin (NI), need mechanical ventilation (NMV), and duration of mechanical ventilation (DMV) in intensive care unit (ICU) trauma patient admissions. METHODS One-hundred ten trauma patients were included in this prospective cohort study. The...

There are good theoretical reasons for earlier intervention in neonates likely to develop chronic neonatal lung disease (CNLD). Very low birthweight (VLBW) neonates who receive artificial ventilation are at high risk of CNLD. A test was therefore developed to predict CNLD based on clinical and radiological information readily available at 7 days of age in VLBW neonates. Logistic regression anal...

The aim of this paper is to compare the glaucoma diagnostic reliability of two optic disc parameters: the relative cup area size determined by the Heidelberg retina tomography and the relative pallor area size determined by the proposed algorithm of the optic disc image analysis. Both parameters were measured for 240 normal healthy eyes and 240 glaucomatous eyes. The diagnostic reliability of s...

multiple diagnostic tools are used by emergency physicians, every day. in addition, new tools are evaluated to obtain more accurate methods and reduce time or cost of conventional ones. in the previous parts of this educational series, we described diagnostic performance characteristics of diagnostic tests including sensitivity, specificity, positive and negative predictive values, and likeliho...

UNLABELLED Receiver operating characteristic (ROC) analysis is usually applied in bioinformatics to evaluate the abilities of biological markers to differentiate between the presence or absence of a disease. It includes the derivation of the useful scalar performance measure area under the ROC curve for binary classification tasks. As real applications often deal with more than two classes, mul...

Interleukin-6 is a biomarker of inflammation which has been suggested as having potential discriminatory ability for myocardial infarction. Because of its high assaying cost it is very expensive to evaluate this marker. In order to reduce this cost we propose pooling the specimens. In this paper we examine the efficiency of ROC curve analysis, specifically the estimation of the area under the R...

objective: the two most frequent hypochromic microcytic anemias are β- thalassemia minor (btm) and iron deficiency anemia (ida). several discrimination indices have been proposed to quickly discriminate these similar entities via parameters obtained from automated blood count analyzers. the aim of this study to evaluate the diagnostic reliability of ten discrimination indices in the differentia...