نتایج جستجو برای: ardestan rig introduction today
تعداد نتایج: 455708 فیلتر نتایج به سال:
Japanese encephalitis virus (JEV) infection can cause central nervous system disease with irreversible neurological damage in humans and animals. Evidence suggests that overactivation of microglia leads to greatly increased neuronal damage during JEV infection. However, the mechanism by which JEV induces the activation of microglia remains unclear. Toll-like receptor 3 (TLR3) and retinoic acid-...
Lys63-linked polyubiquitination of RIG-I is essential in antiviral immune defense, yet the molecular mechanism that negatively regulates this critical step is poorly understood. Here, we report that USP21 acts as a novel negative regulator in antiviral responses through its ability to bind to and deubiquitinate RIG-I. Overexpression of USP21 inhibited RNA virus-induced RIG-I polyubiquitination ...
Retinoic acid inducible-gene I (RIG-I) functions as one of the major sensors of RNA viruses. DDX58, which encodes the RIG-I protein, has been newly identified as a susceptibility gene in psoriasis. Here, we show that the activation of RIG-I by 5'ppp-dsRNA, its synthetic ligand, directly causes the production of IL-23 and triggers psoriasis-like skin disease in mice. Repeated injections of IL-23...
Bronchial epithelial cells play an important role in airway host defence, and interferon (IFN)-gamma controls immune reactions by regulating the expression of various genes in bronchial epithelial cells. Signal transducer and activator of transcription 1 (STAT1) is the key transcriptional factor in IFN-gamma signalling. Retinoic acid-inducible gene-I (RIG-I) is a member of the DExH box family o...
Activation of the innate immune receptor retinoic acid-inducible gene I (RIG-I) by its specific ligand 5'-triphosphate-RNA (3pRNA) triggers antitumor immunity predominantly via NK cell activation and direct apoptosis induction in tumor cells. However, how NK cells are mobilized to attack the tumor cells remains elusive. Here, we show that RIG-I activation induced the secretion of extracellular ...
Commissural axons in vertebrates and insects are initially attracted to the nervous system midline, but once they reach this intermediate target they undergo a dramatic switch, becoming responsive to repellent Slit proteins at the midline, which expel them onto the next leg of their trajectory. We have unexpectedly implicated a divergent member of the Robo family, Rig-1 (or Robo3), in preventin...
We present a facial deformation system that adapts a generic facial rig into different face models. The deformation is based on labels and allows transferring specific facial features between the generic rig and face models. High quality physics-based animation is achieved by combining different deformation methods with our labeling system, which adapts muscles and skeletons from a generic rig ...
Retinoic acid-inducible gene I (RIG-I) recognizes double-stranded viral RNAs (dsRNAs) containing two or three 5' phosphates. A few reports of 5'-PPP-independent RIG-I agonists have emerged, but little is known about the molecular principles underlying their recognition. We recently found that the bent duplex RNA from the influenza A panhandle promoter activates RIG-I even in the absence of a 5'...
The ability to perform rolling contact fatigue (RCF) experiments in wheel–rail material is provided by a new small–scale test rig, manifesting the actual dynamic behaviour of the railway system. In this paper, a multi-body dynamics (MBD) model is proposed, simulating the vibration behaviour of the prescribed rig. The new testing facility is modelled using a three-dimensional model of the vehicl...
the present research aims to apply several approaches for suitability evaluation of lands under cultivation ofalfalfa and barley in chaharmil mechanized farming center, ardestan town, isfahan province, iran. climatic andsoil maps of the climate and soil data were provided in raster format. land evaluation carried out using maximumlimitation, parametric and multi-criteria (analytical hierarchy p...
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