The main objective of information retrieval (IR) systems is to retrieve information or information objects relevant to user requests and possible needs. In IR tests, retrieval effectiveness is established by comparing IR systems retrievals (systems relevance) with users’ or user surrogates’ assessments (user relevance), where user relevance is treated as the gold standard for performance evalua...

The main objective of information retrieval (IR) systems is to retrieve information or information objects relevant to user requests and possible needs. In IR tests, retrieval effectiveness is established by comparing IR systems retrievals (systems relevance) with users’ or user surrogates’ assessments (user relevance), where user relevance is treated as the gold standard for performance evalua...

Amos Golan Department of Economics, American University, Roper 200, 4400 Massachusetts Ave., NW, Washington, DC 20016, USA.

Anti-miRNA antisense inhibitors (AMOs) have demonstrated their utility in miRNA research and potential in miRNA therapy. Here we report a modified AMO approach in which multiple antisense units are engineered into a single unit that is able to simultaneously silence multiple-target miRNAs, the multiple-target AMO or MTg-AMO. We validated the technique with two separate MTg-AMOs: anti-miR-21/ant...

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MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression post-transcriptionally. Previous studies, which characterized miRNA function, revealed their involvement in fundamental biological processes. Importantly, miRNA expression is deregulated in many human diseases. Specific inhibition of miRNAs using chemically modified anti-miRNA oligonucleotides (AMOs) can be a potential th...

Information becomes a more and more valuable asset in today’s organizations. Therefore the need of creating an integrated view over all available data sources arises. Several technical problems must be overcome in the design and implementation of a system for integrating different data sources. To the main obstacles count autonomy, data heterogeneity and different query capabilities of the repo...

In this thesis we develop a wrapper for scientific data stored in ROOT files using Amos II, a functional DBMS. ROOT is an object-oriented framework for representing high-energy physics data. We investigate possible ways to represent ROOT C++ objects in a functional data model and propose a simple and fast mapping method. We define a schema to represent ROOT object storage containers, objects an...