نتایج جستجو برای: arachidonoyl dopamine

تعداد نتایج: 45801  

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2012
Alexandra Wojtalla Frank Herweck Michaela Granzow Sabine Klein Jonel Trebicka Sebastian Huss Raissa Lerner Beat Lutz Frank Alexander Schildberg Percy Alexander Knolle Tilman Sauerbruch Manfred Vincenz Singer Andreas Zimmer Sören Volker Siegmund

The endocannabinoid system is a crucial regulator of hepatic fibrogenesis. We have previously shown that the endocannabinoid anandamide (AEA) is a lipid mediator that blocks proliferation and induces death in hepatic stellate cells (HSCs), the main fibrogenic cell type in the liver, but not in hepatocytes. However, the effects of other endocannabinoids such as N-arachidonoyl dopamine (NADA) hav...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2006
Garry Milman Yehoshua Maor Saleh Abu-Lafi Michal Horowitz Ruth Gallily Sandor Batkai Fong-Ming Mo Laszlo Offertaler Pal Pacher George Kunos Raphael Mechoulam

The endocannabinoid N-arachidonoyl ethanolamine (anandamide), found both in the CNS and in the periphery, plays a role in numerous physiological systems. One might expect that the chemically related N-arachidonoyl-L-serine (ARA-S) could also be formed alongside anandamide. We have now isolated ARA-S from bovine brain and elucidated its structure by comparison with synthetic ARA-S. Contrary to a...

Journal: :The Journal of biological chemistry 2004
Sanjay Srivastava Matthew Spite John O Trent Matthew B West Yonis Ahmed Aruni Bhatnagar

Oxidation of unsaturated phospholipids results in the generation of aldehyde side chains that remain esterified to the phospholipid backbone. Such "core" aldehydes elicit immune responses and promote inflammation. However, the biochemical mechanisms by which phospholipid aldehydes are metabolized or detoxified are not well understood. In the studies reported here, we examined whether aldose red...

2014
William John Redmond Liuqiong Gu Maxime Camo Peter McIntyre Mark Connor

Background and purpose. Arachidonic acid (AA) and its derivatives are important modulators of cellular signalling. The transient receptor potential cation channel subfamily A, member 1 (TRPA1) is a cation channel with important functions in mediating cellular responses to noxious stimuli and inflammation. There is limited information about the interactions between AA itself and TRPA1, so we inv...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
Guillaume Barbara Abdelkrim Alloui Joël Nargeot Philippe Lory Alain Eschalier Emmanuel Bourinet Jean Chemin

Lipoamino acids are anandamide-related endogenous molecules that induce analgesia via unresolved mechanisms. Here, we provide evidence that the T-type/Cav3 calcium channels are important pharmacological targets underlying their physiological effects. Various lipoamino acids, including N-arachidonoyl glycine (NAGly), reversibly inhibited Cav3.1, Cav3.2, and Cav3.3 currents, with potent effects o...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008
Nóra Dobrosi Balázs I Tóth Georgina Nagy Anikó Dózsa Tamás Géczy László Nagy Christos C Zouboulis Ralf Paus László Kovács Tamás Bíró

We had previously shown that both locally produced endocannabinoids and exocannabinoids, via cannabinoid receptor-1 (CB1), are powerful inhibitors of human hair growth. To further investigate the role of the cannabinoid system in pilosebaceous unit biology, we have explored in the current study whether and how endocannabinoids have an impact on human sebaceous gland biology, using human SZ95 se...

Journal: :The Biochemical journal 1992
T Cronholm M Viestam-Rains J Sjövall

Phosphatidylinositol (PtdIns), phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 4,5-diphosphate [PtdIns(4,5)P2] were isolated from the pancreas of rats fed an ethanol-containing liquid diet for 24 days and from the corresponding pair-fed controls. The isolation involved chromatography on a lipophilic anion exchanger in the phosphate form. The species composition was determin...

2014
James J. Burston Stephen G. Woodhams

The endocannabinoid (EC) system consists of two main receptors: cannabinoid type 1 receptor cannabinoid receptors are found in both the central nervous system (CNS) and periphery, whereas the cannabinoid type 2 receptor cannabinoid receptor is found principally in the immune system and to a lesser extent in the CNS. The EC family consists of two classes of well characterised ligands; the N-acyl...

Journal: :The Biochemical journal 1992
M Spaargaren S Wissink L H Defize S W de Laat J Boonstra

The production of arachidonic acid (AA), which is involved in mitogenic signalling by epidermal growth factor (EGF), is most directly accomplished by the action of phospholipase A2 (PLA2). We demonstrate that EGF treatment of intact NEF cells rapidly activates a cytosolic PLA2, as measured in cell-free extracts by the release of radiolabelled AA from exogenously added 1-stearoyl-2-[1-14C]arachi...

Journal: :Current drug targets. CNS and neurological disorders 2005
Franjo Grotenhermen

Since the discovery of an endogenous cannabinoid system, research into the pharmacology and therapeutic potential of cannabinoids has steadily increased. Two subtypes of G-protein coupled cannabinoid receptors, CB(1) and CB(1), have been cloned and several putative endogenous ligands (endocannabinoids) have been detected during the past 15 years. The main endocannabinoids are arachidonoyl ethan...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید