The authors introduce a new vision for providing computing services for connected devices. It is based on the key concept that future computing resources will be coupled with communication resources, for enhancing user experience of the connected users, and also for optimising resources in the providers’ infrastructures. Such coupling is achieved by Joint/Cooperative resource allocation algorit...

Contemporary quantitative mass spectrometry provides fascinating opportunities in defining the stoichiometry of high-molecular weight complexes or multiprotein platforms. The composition stoichiometry of multiprotein platforms is a key to understand the regulation of complex signaling pathways and provides a basis for constructing models in systems biology. Here we present an improved AQUA tech...

BACKGROUND The prevalence of allergy in athletes is increasing, and its risk varies across sports. The risk is dependent mainly on the ventilation rate and environmental factors; however, the prevalence of allergy in elite runners remains unknown. Therefore, the aim of this study was to screen allergy symptoms in elite marathon runners by using a validated questionnaire for screening allergy in...

BACKGROUND The diffusion of antibiotics through the outer membrane is primarily affected by the porin super family, changes contribute to antibiotic resistance. Recently we demonstrated that the CpxAR two-component signaling system alters the expression of an uncharacterized porin OmpC(KP), to mediate antimicrobial resistance in K. pneumoniae. PRINCIPAL FINDINGS In this study, functional char...

Substance P (SP) is the prototypic neuropeptide associated with emotional stress and neurogenic perifollicular inflammation released by sensory nerve fibers. It also promotes human hair follicle (HF) immune privilege collapse catagen development ex vivo, has thus been implicated in stress-related loss, ranging from telogen effluvium to alopecia areata. Since SP stimulates mitochondrial release ...

BACKGROUND The Voltage Dependent Anion Channel (VDAC) is involved in control of autism. Treatments, including coenzyme Q, have had some success on autism control. DATA SOURCES Correlation of porin redox activity and expression of autism is based on extensive literature, especially studies of antibodies, identification of cytosolic nicotinamide adenine dinucleotide reduced (NADH) dehydrogenase...

The mitochondrial porin or VDAC (Voltage-Dependent Anion Channel), the pore-forming structure responsible for the high permeability of the outer mitochondrial membrane, was found to be one of only three mitochondrial proteins bound by [14C]dicyclohexylcarbodiimide (DCCD) at low dosages (1.5 nmol/mg of mitochondrial porin) (De Pinto, V., Tommasino, M., Benz, R., and Palmieri, F. (1985) Biochim. ...