We evaluated the effect of sample volume and citrate concentration on results of routine coagulation assays (prothrombin time [PT] and activated partial thromboplastin time [APTT]). The study was performed on samples obtained from healthy persons and patients receiving oral anticoagulant therapy. Standard evacuated tubes (3.2% and 3.8% sodium citrate) were filled to varying total sample volumes...

Two flavonoids, rutin and hesperidin, were investigated in vitro for anticoagulant activity through coagulation tests: activated partial thromboplastin time (aPTT), prothrombin time (PT) and thrombin time (TT). Only an ethanolic solution of rutin at the concentration of 830 µM prolonged aPTT, while TT and PT were unaffected. In order to evaluate whether the prolongation of aPTT was due to the d...

凝固波形解析（clot waveform analysis: CWA）には，活性化部分トロンボプラスチン時間（activated partial thromboplastin time: APTT），プロトロンビン時間（prothrombin PT），トロンビン時間（thrombin TT）などがあり，エビデンスが集積されつつある．また，生理的な凝固能を評価するために，種々の修正CWAが開発されつつある．修正CWAには，CWA-PT/APTT，CWA-希釈PT（small amount TF induced FIX activation: sTF/FIXa），CWA-希釈TT，global coagulation and fibrinolysis testなどがある．CWA-sTF/FIXaはpeak heightの増加で過凝固状態を，peak timeの延長で血小板減少を示唆する．...

BACKGROUND The indwelling venous catheter such as Dual-Cath or Twin-Cath is widely used in haemodialysis. Although the manufacturer recommends filling the catheter lumen with heparin after the dialysis session to prevent clotting, little is known about the systemic effects of such a procedure. METHODS Twenty haemodialysis patients with Dual-Cath were studied. Dialysis anticoagulation was achi...

SARS-CoV-2 causing corona virus disease 2019 (COVID-19) is the most common infection in recent days worldwide. Rapidly evolving from epidemic outbreak Wuhan, China on 29 December 2019, third known that causes fatal respiratory diseases humans. The roles of biomarkers a blood sample diagnosis COVID-19 patients who have visited hospital with history fever has been evaluated. A retrospective study...

BACKGROUND Rivaroxaban is a direct oral anticoagulant designed to dispense with the necessity of laboratory monitoring. However, monitoring rivaroxaban levels is necessary in certain clinical conditions, especially in the critical care setting. METHODS This is a diagnostic accuracy study evaluating sensitivity and specificity of prothrombin time (PT), activated partial thromboplastin time (aP...

We measured the plasma D-dimer (DD) concentration in 205 dogs. Simultaneously, fibrinogen/fibrin degradation products (FDPs) concentration, platelet (PLT) count, prothrombin time (PT), activated partial thromboplastin time (APTT), and plasma concentrations of fibrinogen (Fib) were measured in the same dogs. From these results, we were able to divide the animals into four groups: control (health...

The effect of lysis timing on bacteriophage (phage) fitness has received little theoretical or experimental attention. Previously, the impact of lysis timing on phage fitness was studied using a theoretical model based on the marginal value theorem from the optimal foraging theory. An implicit conclusion of the model is that, for any combination of host quantity and quality, an optimal time to ...

background: tumor lysis syndrome caused by widespread tumor cell damage may lead to electrolyte imbalances and express as metabolic disturbance causing clinical abnormalities. patients and methods: all patients younger than 16 years with documented malignancy candidate for chemotherapy, in hamedan province of iran were enrolled. results: out of 69 cancer patients the laboratory form of tumor ly...