PURPOSE The impact of a collaborative drug therapy management (CDTM) agreement enabling pharmacist-managed direct thrombin inhibitor (DTI) therapy was evaluated. METHODS A retrospective chart review was conducted to compare selected outcome measures between cohorts of adults who received argatroban or bivalirudin therapy for suspected heparin-induced thrombocytopenia (HIT) before (n = 25) and...

INTRODUCTION Sickle cell disease is a collection of autosomal recessive genetic disorders. It includes homozygous HbSS and double heterozygote combinations such as HbSC. Central and West Africa bears a significant burden of HbSC disease. METHODS Prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen concentration (FC) and platelet count (PC) were determined in 41 HbSC...

An outbreak of respiratory illness, officially named Coronavirus Disease 2019 (COVID-19), has spread rapidly worldwide. The domestic situation been controlled, now the resumption production and work as well people's normal life accelerating. We focused this article on laboratory changes in infection confirmed case COVID-19 hospitalized to clarify immune characterizations coagulation system. Coa...

BACKGROUND The risk-benefit ratio of early vs late heparinization for acute stroke with nonvalvular atrial fibrillation remains unsettled. OBJECTIVE To clarify the relationship between timing to heparinization and functional outcome in acute cardioembolic stroke. DESIGN Consecutive case series. SETTING Referral center. PATIENTS In 231 patients with stroke and nonvalvular atrial fibrilla...

BACKGROUND Heparin treatment has been recommended for dogs in hypercoagulable states such as disseminated intravascular coagulation, however, potential benefits have to be balanced against the bleeding risk if overdosage occurs. A better understanding of the pharmacology of heparin and tests to monitor heparin therapy in dogs may help prevent therapeutic hazards. OBJECTIVES The purpose of thi...

Background: Hyperglycemia, hyperinsulinemia, and insulin resistance have been observed in various studies as the causes of changes components that play an important role hemostasis. Purpose:This study aims to analyze relationship between duration Type 2 DM hemostatic conditions PT APTT. Methods: This belongs observational with a cross sectional approach using plasma blood samples filled anticoa...

Background: Coagulation, also known as blood clotting, is the process by which convert from a liquid to gel, forming clot. It referred haemostasis, stopping of loss damaged vessel, followed repair.
 Material and methods: This was cross sectional study conducted at albawasla medical laboratory, Khartoum, Sudan during period August November, 2021 evaluate effect time hemolysis on prothrombin...

Obstetric hemorrhage is the leading cause of maternal mortality and morbidity worldwide. This study was carried out to investigate the effect of obstetric hemorrhage on the prothrombin time (PT), activated partial thromboplastin time (APTT), and platelet count (PLC). Women with obstetric hemorrhage were divided into two categories, women with antepartum hemorrhage (APH) and those with postpartu...

BACKGROUND Extracorporeal membrane oxygenation (ECMO) or pumpless extracorporeal lung assist (pECLA) requires effective anticoagulation. Knowledge on the use of argatroban in patients with acute respiratory distress syndrome (ARDS) undergoing ECMO or pECLA is limited. Therefore, this study assessed the feasibility, efficacy and safety of argatroban in critically ill ARDS patients undergoing ext...