In search for yet uncharacterized proteins involved in lipid metabolism of the chicken, we have isolated a hitherto unknown protein from the serum lipoprotein fraction with a buoyant density of ≤1.063 g/ml. Data obtained by protein microsequencing and molecular cloning of cDNA defined a 537 bp cDNA encoding a precursor molecule of 178 residues. As determined by SDS-PAGE, the major circulating f...

Elevated blood levels of apolipoprotein(a), the component of lipoprotein(a) that distinguishes it from low density lipoprotein, are a major risk factor for atherosclerosis. The apolipoprotein(a) gene is highly similar to the pasminogen gene and to at least four other genes or pseudogenes. The 5' untranslated and flanking sequences of these six genes contain extensive regions of near identity an...

Lipoprotein (a) [Lp(a)] was first described by Berg as a genetic variant of low density lipoprotein (LDL) more than twenty-five years ago (1). Lp(a) lipid composition is similar to that of LDL, and floats in a density range of 1.051.125g/ml. Its protein moiety contains a specific glycoprotein, apolipoprotein (a) [apo(a)], in addition to apo B-100. Recently, the cDNA sequence of human apo(a) was...

The Watanabe heritable hyperlipidemic rabbit (WHHL) provides an experimental animal model for the low density lipoprotein (LDL) receptor defect present in patients homozygous for familial hypercholesterolemia (FH). Both WHHL rabbits and FH patients have a four- to sevenfold increase in plasma levels of apolipoprotein E (apo E). To determine the etiology for the elevated apo E concentrations, ki...

INTRODUCTION Dyslipidemia is an important risk factor in cardiovascular diseases. Different studies have shown that Apolipoprotein B (Apo B) is one of the best predictors in determining cardiovascular diseases and patients follow up after cardiovascular events. We hypothesized that there is a relation between Apo B levels and cardiovascular events in patients who have myocardial infarction (MI)...

Background. The "1Western" diet, sex, and apolipoprotein (Apo) E polymorphism have been implicated as codeterminants of lipid levels. Methods and Results. In a retrospective analysis, we evaluated the combined impact of dietary fat, sex, and Apo E phenotype on lipoprotein levels in 67 subjects fed two contrasting, metabolically controlled diets: one a "Western" diet, with a low polyunsaturated ...

ABSTRACT However, whether the beneficial effect of fenofibrate on the endothelium is related to reduction of ADMA level in individuals with diabetes mellitus (DM) is not known, and the current study aimed to address this issue. Aim: A total of 60 patients with type 2 DM and dyslipidemia (aged 45 ± 8 years; mean ± SD) were compared to 59 healthy controls without type 2 DM and normolipidemia (age...

The fasting plasma lipid, lipoprotein and apolipoprotein profiles were determined in 14 healthy Nigerian male athletes and controls matched for sex and anthropometric parameters. The mean levels of total cholesterol (P < 0.05), low-density lipoprotein (LDL) cholesterol, apolipoprotein (apo) AII and E were significantly lower (P < 0.01) in the athletes than in the controls. However, there were n...

Lipid and apolipoprotein serum levels as a consequence of excessive nutrition in the overweight individuals with familial combined hyperlipidemia (FCHL) in comparison with the obese ones are studied only sporadically. In this study, the effect of overweight and obesity in subjects with FCHL on serum lipids and apolipoproteins was investigated. The participants were 36 overweight and 10 obese me...