A ortic coarctation was one of the first types of congenital heart diseases to be treated successfully with surgery. Despite initial optimism, surgical relief of aortic narrowing does not cure the underlying vascular problem. Patients with previously repaired coarctation have a significantly reduced life expectancy and continue to be at risk of major complications throughout life including hype...

BACKGROUND The use of balloon coarctation angioplasty instead of surgery as treatment for unoperated coarctation of the aorta is controversial. The efficacy and complications of the two procedures have not been studied before in a prospective fashion. METHODS AND RESULTS Thirty-six patients were prospectively randomized to either angioplasty (20 patients) or surgery (16 patients). Immediate r...

•Here, we are presenting a very rare case of coarctation of abdominal aorta where a transcatheter closure by a vascular plug of the feeding collateral to a large aneurysm has been done. To the best of our knowledge, this mode of therapy has never been described in persons with coarctation of abdominal aorta.•Aneurysms in patients with an abdominal coarctation are not well recognized. This is pr...

Probucol (PB) is a drug commonly used for the treatment of hyperlipidemia and atherosclerosis. In our previous study, we have proved that PB can ameliorate abdominal aortic aneurysm (AAA) induced by elastase in mice through its anti-inflammatory and anti-oxidative effect. In this study, the water solubility and oral absorption of PB were improved by encapsulating PB into nanostructured lipid ca...

To test the hypothesis that prostanoids contribute to angiotensin II-induced vascular contraction, we compared the effect of angiotensin II on isometric tension development by rings of descending thoracic aorta bathed in Krebs' bicarbonate buffer with and without indomethacin (10 microM) to inhibit cyclooxygenase, CGS13080 (10 microM) to inhibit thromboxane A2 synthesis, or SQ29548 (1 microM) t...

Background: Aortic coarctation (CoA) is a common congenital aortic disease, which often accompanied by root disease. This study aimed to explore the simultaneous surgical treatment of replacement and ascending-abdominal bypass grafting for patients with CoA