OBJECTIVE The nucleus accumbens (NAc) receive histaminergic neurons from tuberomammillary nuclei. There are reports indicating that central histamine systems are involved in many physiological behavioral processes, including anxiety. The aim of the present study was to assess whether the histaminergic system of the NAc is involved in anxiety-related behaviors. METHODS Rats were anesthetized w...

The aim of this study was to explore effects on anxiety-like behavior of D1 dopamine receptor agonist, SKF-38393, and of D1 dopamine receptor antagonist, SCH-23390, given alone or in combination with a low dose of 17β-estradiol (17β-E2) to ovariectomized (OVX) rats. Two weeks after surgery, OVX rats began 14 days of treatment with the vehicle, a low dose of 17 β -E2 (5.0 μg/rat, s.c.), SKF-3839...

Spiranthera odoratissima A. St. Hil. (manacá) is used in folk medicine to treat renal and hepatic diseases, stomachache, headaches and rheumatism. A central nervous system (CNS) depressant effect of the hexane fraction from the ethanolic extract of this plant has been described. β-caryophyllene, the main component of this essential oil, is a sesquiterpene compound with anti-inflammatory propert...

conclusions our results demonstrated that the extract of ob could induce anxiolytic effect in rats after 1 week oral administration. the effect of ob was not induced through changes in motor activity. further investigations are necessary for pharmacological providing of ob and better understanding of its anxiolytic properties and neurobiological mechanisms. results the results showed that after...

Background: The most widely prescribed medications for anxiety disorders are the Benzodiazepines; however, they have prominent side effects. Thus, interest in alternative medicine that affects the mind is growing. In Morocco folk medicine, the use of Mercurialis annua is commonly recommended for relief of anxiety, although no scientific information supporting this use is available and therefore...

Due to sedation, anticonvulsant and anti-pain effects, Leonuruscardiaca hashad a special place in traditional medicine of Iran and any of countries. The chemical composition of this plant contain alkaloids (stachydrine, Leonurine), Iridoid glycosides, labdanediterpene and terpene lactones like (Leo carlin and macrobid side), flavonoids, phenolic acids and tannins that these substances may affec...

Aim: To study and compare the effect of different pediatric medication on tooth-colored restorative materials. Method: One fifty specimens, 50 each material RMGIC, Compomer Composite were obtained using circular acrylic mold with a diameter 5mm thickness 2mm A2 shade for standardization. They further divided into five subgroups multivitamin, antiepileptic, anxiolytic, bronchodilator distilled w...

INTRODUCTION Anxiety is among the most common and treatable mental disorders. Adrenergic and cannabinoid systems have an important role in the neurobiology of anxiety. The elevated plus-maze (EPM) has broadly been used to investigate anxiolytic and anxiogenic compounds. The present study investigated the effects of intraperitoneal (IP) injection of cannabinoid CB1 receptor antagonist (AM251) in...

OBJECTIVE Argemone mexicana is a Papaveracea plant; some reports have shown their antibacterial, anti-cancer, sedative and probably anti-anxiety properties. From their aerial parts, flavonoids and alkaloids have been isolated, which are intrinsically related to some actions on the central nervous system. The aim of this study was to evaluate the anxiolytic-like effects of the plant, using its e...

Anxiety disorders are one of the most common mental health problems worldwide, but the exact pathophysiology remains largely unknown. It has been demonstrated previously that administration of exogenous ketone supplement KSMCT (ketone salt/KS + medium chain triglyceride/MCT oil) by intragastric gavage for 7 days decreased the anxiety level in genetically absence epileptic Wistar Albino Glaxo/Ri...