Abstract Background Analysis of viral protein–protein interactions is an essential step to uncover the protein functions and molecular mechanism for assembly a complex. We employed mammalian two-hybrid system screen all proteins SARS-CoV-2 interactions. Results Our study detected 48 interactions, 14 which were firstly reported here. Unlike Nsp1 SARS-CoV, has most interacting partners among like...

Viruses possess many strategies to impair host cellular responses to infection. Nuclear export of host messenger RNAs (mRNA) that encode antiviral factors is critical for antiviral protein production and control of viral infections. Several viruses have evolved sophisticated strategies to inhibit nuclear export of host mRNAs, including targeting mRNA export factors and nucleoporins to compromis...

Pokeweed antiviral protein (PAP), a 29-kDa protein isolated from Phytolacca americana, inhibits translation by catalytically removing a specific adenine residue from the large rRNA of the 60S subunit of eukaryotic ribosomes. In addition to its ribosome-inactivating ability, PAP has potent antiviral activity against many plant and animal viruses, including HIV. We recently described the isolatio...

1. Helenine prevents the establishment in mice of passive viral immunity by anti-Semliki serum of swine, rabbit, or guinea pig origin. 2. A period of 12 days must elapse, between the antiviral serum administration and challenge with virus, for prevention of the establishment of passive immunity to become apparent. This period is believed to correspond to that in which injected antibody persists...

COVID-19 is still a global pandemic. The transmission very fast and wide. Its prevalence continues to increase. There no specific antiviral drug for SARS CoV 2 yet. This study aims find lead compounds from derived spices that can work as multitarget CoV-2 antivirals. target of action chosen in this the main protease enzyme non-structural protein 3 (NSP3) macrodomain. Antiviral on both targets a...

Pokeweed antiviral protein (PAP) is a plant-derived N-glycosidase that exhibits antiviral activity against several viruses. The enzyme removes purine bases from the messenger RNAs of the retroviruses Human immunodeficiency virus-1 and Human T-cell leukemia virus-1. This depurination reduces viral protein synthesis by stalling elongating ribosomes at nucleotides with a missing base. Here, we tra...

The activity of the antiviral protein induced by various ratios of poly rI.rC and diethylaminoethyl (DEAE)-dextran was studied. It was found that, when large doses of poly rI.rC were used, very little viral interference was observed. This effect was initially attributed to the cells being refractory for production of antiviral protein. Subsequent experiments offered alternative explanations sug...

Skin plays a vital role in immune defense which maintain homeostasis with commensals and quickly detect resist pathogen invasion. Antiviral immunity is dysregulated among broad spectrum of skin conditions. The 2’-5’-oligoadenylate synthetase (OAS) protein family comprises OAS1, OAS2, OAS3, OASL, can be induced by interferons (IFNs) exert antiviral activity. Recent studies also highlight IL-27 i...

The efforts in dealing with COVID-19 various aspects are continuously being carried out, such as the photocatalytic process. Interestingly, TiO2 plays an important role environmentally friendly photocatalyst a visible and UV absorption range. increase antiviral performance of this compound is further maximized by formulating TiO2-based composites doping it to reduce bandgap. This review aims de...

Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) is the virus that causes COVID-19 which responsible for illness infection in humans. The was first identified China 2019 and later spread to other countries worldwide. This study aims identify bioactive compounds from mangosteen (Garcinia mangostana L.) as an antiviral agent via dual inhibitor mechanisms against two SARS-CoV-2 proteas...