The aim of this study was to evaluate the sensitivity and specificity of a whole blood interferon-γ release assay, the QuantiFERON®-TB Gold In-Tube (QFT-GIT) test, in the diagnosis of Mycobacterium tuberculosis (MTB) infection, and to assess its monitoring role during antitubercular treatment. In total, 20 patients received the QFT test, along with other commonly-used tests, prior to, and follo...

In the current era of modern medicine, neglected tropical disorders though rare, still remain a cause significant morbidity in sufferers. Actinomycetoma is one such disease commonly seen rural population countries. Due to presence other infectious diseases with similar presentation and low yield on cultures, there may be delay correct diagnosis treatment resource poor settings. We present 35 ye...

The aim of the present investigation was to develop a novel dosage form of rifampicin and isoniazid to minimize degradation of rifampicin in acidic medium, to modulate the release of rifampicin in the stomach and isoniazid in the intestine, and to provide pediatric compliance. Rifampicin slowly diffuses out through this hydrogel matrix, thereby sustaining its release (50.08%). The release of is...

Allium sativum has been reported to have a lot of therapeutic potentials such as antihypertensive, antimicrobial and hypocholesterolemic. This study has investigated its effect on anti-tubercular drugs hepatotoxicity. Wistar albino rats were pretreated and co-administered orally with aqueous solution of Allium sativum. Eighteen rats were divided into six groups of three rats each. Group 1 were ...

A series of 4-(2,5-dimethylpyrrol-1-yl)/4-pyrrol-1-yl benzoic acid hydrazide analogs, some derived triazoles, azetidinones, thiazolidinones, and pyrroles have been synthesized in good yields and structures of these compounds were established by IR, (1)H NMR, (13)C NMR, mass spectral, and elemental analysis. These compounds were evaluated for their preliminary in vitro antibacterial, antifungal,...

Treatment against tuberculosis can lead to the selection of drug-resistant Mycobacterium strains. To tackle this serious threat, new targets from M. are needed develop novel effective drugs. In work, we aimed provide a possible workflow validate and inhibitors by combining genetic, in silico, enzymological approaches. CanB is one three β-carbonic anhydrases that catalyze reversible reaction CO2...