Abstract. Ragsasilp A, Saensouk P, S. 2022. Ginger family from Bueng Kan Province, Thailand: Diversity, conservation status, and traditional uses. Biodiversitas 23: 2739-2753. The objective of this study was to determine the diversity, uses Zingiberaceae in Thailand. collected during field surveys northeastern Thailand between January December 2021. Three tribes, 13 genera, 67 species were foun...

BACKGROUND Pruritus (itch) is a frequent, burdensome and difficult-to-treat symptom in patients with cholestasis. Fibrates are currently under investigation for the treatment of primary biliary cholangitis in patients with a suboptimal response to ursodeoxycholic acid. Moreover, there is empirical evidence for a possible antipruritic effect. We aim to prove this in a randomized controlled trial...

BACKGROUND Phosphodiesterase 4 (PDE4), which catalyses the conversion of cyclic adenosine 3',5'-monophosphate (cAMP) to 5'-AMP, plays a critical role in the pathogenesis of inflammatory disorders. Pruritus is the main symptom of dermatitides, such as atopic dermatitis, and is very difficult to control. Recent studies have shown that the activation of proteinase-activated receptor 2 (PAR2) is in...

BACKGROUND Histamine is the prototypical pruritogen used in experimental itch induction. However, in most chronic pruritic diseases, itch is not predominantly mediated by histamine. Cowhage-induced itch, on the other hand, seems more characteristic of itch occurring in chronic pruritic diseases. OBJECTIVES We tested the validity of cowhage as an itch-inducing agent by contrasting it with the ...

p ROPOFOL IS A COMMONLY USED intravenous anesthetic agent. Chemically, propofol is a lipophilic, sterically indered alkylated phenol that is a very weak acid.1,2 Pharmaokinetic and pharmacodynamic properties make propofol a seful drug in everyday anesthesia with rapid and clear emerence, precise control of the level of sedation, and lack of umulative effects even after prolonged administration....

PURPOSE OF THE REVIEW Uremic pruritus (UP) is a common discomfort of dialysis-dependent end-stage renal disease. Some studies suggest a neuropathic cause of UP. Gabapentin, an anticonvulsant, has shown promising results as an emerging drug to treat this condition. OBJECTIVE An updated qualitative systematic review was conducted to evaluate its efficacy and safety in hemodialysis patients. S...

BACKGROUND Atopic dermatitis (AD) is a common skin disease characterized by recurrent pruritic inflammatory skin lesions resulting from structural and immune defects of the skin barrier. Previous studies have shown the clinical efficacy of Avène thermal spring water in AD, and a new microorganism, Aquaphilus dolomiae was suspected to contribute to these unique properties. The present study eval...

OBJECTIVE Antagonism of the central nervous system inhibitor neurotransmitter gamma-Aminobutyric acid (GABA) or serotonergic system activation is an important factor in the pathogenesis of intrathecal morphine-induced pruritus. This study tested the hypothesis that preoperative use of ondansetron, gabapentin or mirtazapine can prevent morphine-induced pruritus. METHODS We randomly allocated 8...

Uremic pruritus has a great negative influence on quality of life in hemodialysis (HD) patients and, importantly, negatively affects mortality risk. Recently, nalfurafine hydrochloride, an opioid κ-selective agonist, has been officially approved for resistant pruritus in HD patients on the basis of a well-evidenced clinical trial in Japan. From clinical observation, it has been suggested that t...