Glucocorticoids such as dexamethasone are widely used as comedication in the treatment of head and neck cancer, e.g., to improve appetite and decrease weight loss and fatigue in patients with advanced disease or as antiallergic and antiemetic prophylaxis during anti-EGFR therapy. However, the literature suggests that dexamethasone induces resistance to antineoplastic agents in many solid tumor ...

In addition to its anticoagulant properties, heparin (HP), a complex polysaccharide covalently linked to a protein core, inhibits proliferation of several cell types including pulmonary artery smooth muscle cells (PASMCs). Commercial lots of HP exhibit varying degrees of antiproliferative activity on PASMCs that may due to structural differences in the lots. Fractionation of a potent antiprolif...

The aim of this work was to study the antiproliferative effect of a tincture from fruits of Angelica archangelica and the active components using the human pancreas cancer cell line PANC-1 as a model. Significant dose-dependent antiproliferative activity was observed in the tincture with an EC50 value of 28.6 microg/ml. Strong antiproliferative activity resulted from the two most abundant furan...

Three human IFN-alpha hybrids, HY-1 [IFN-alpha21a(1-75)/alpha2c(76-165)], HY-2 [IFN-alpha21a(1-95)/alpha2c(96-165)], and HY-3 [IFN-alpha2c(1-95)/alpha21a(96-166)], were constructed, cloned, and expressed. The hybrids had comparable specific antiviral activities on Madin-Darby bovine kidney (MDBK) cells but exhibited very different antiproliferative and binding properties on human Daudi and WISH...

Restenosis prevention continues to be a challenge in interventional cardiology. Clinical trials on drug eluting stents (DES) suppressing neointimal proliferation by sustained release of antiproliferative drugs have shown excellent results in reducing restenosis. DES are well accepted in the prevention and therapy of coronary restenosis. Meanwhile, concerns have been raised that DES while being ...

The green synthesis of silver nanoparticles (AgNPs) using plant extract, the cost-effective solution, and abundance environmental issue have been gaining much attention to scientists. Ganoderma lucidum (GL) commonly known as Lingzhi in Chinese Reishi Japanese, with a proven anticancer benefit, is discovered buffer zone Bach Ma National Park, Nam Dong district, Thua Thien Hue province. In this w...

Abstract A marine specimen of the Red Sea soft coral Dendronephthya sp. was extracted with a mixture n -hexane, diethyl ether, and methanol. One new cytotoxic steroid dendronestadione ( 1 ), five known steroids: dendronesterones A-C 2 – 4 dendrotriol 5 cholesterol 6 ) along 4-oxo-pentanoic acid 7 polyhydroxy alkane hexitol 8 were isolated from extract. The chemical structures metabolites elucid...

Concurrent radiochemotherapy for medulloblastoma includes the microtubule disrupting agent vincristine; however, vincristine alone or as part of a combined treatment regimen is highly toxic. A major goal is therefore to replace vincristine with novel potent chemotherapeutic agents-in particular, with microtubule stabilizing and destabilizing compounds-with a larger therapeutic window. Here, we ...

Over the past few decades, melanoma has shown the fastest growing incidence rate of all cancers. This malignancy is clinically defined by its potential to rapidly metastasize, and advanced metastatic melanomas are highly resistant to existing therapeutic regimens. Here, we report that PPI-2458, a novel, orally active agent of the fumagillin class of irreversible methionine aminopeptidase-2 (Met...

Studies show that kidneys produce 2 ,3 -cAMP, 2 ,3 -cAMP is exported and metabolized to 2 -AMP and 3 -AMP, 2 -AMP and 3 -AMP are metabolized to adenosine, 2 ,3 -cAMP inhibits proliferation of preglomerular vascular smooth muscle cells (PGVSMCs) and glomerular mesangial cells (GMCs), and A2B (not A1, A2A, or A3) adenosine receptors mediate part of the antiproliferative effects of 2 ,3 -cAMP. The...