Thromb Haemost 2006; 95: 900–1 Hyperhomocysteinaemia is a risk factor for thrombosis and recurrent pregnancy loss (1–2). Similar mechanisms appear to mediate thrombosis and pregnancy loss associated with hyperhomocysteinaemia and with antiphospholipid antibodies (3). We report the case of a female patient with an unusual association of hyperhomocysteinemia, normocalcemic hyperparathyroidism, gr...

Catastrophic antiphospholipid syndrome (CAPS) is a rare but potentially life-threatening condition characterized by diffuse vascular thrombosis, leading to multiple organ failure developing over a short period of time in the presence of positive antiphospholipid antibodies (aPL). CAPS is a severe form of antiphospholipid syndrome, developing in about 1% of cases of classic antiphospholipid synd...

Satisfactory results have not yet been obtained in therapy for secondary prevention in ischemic stroke patients with antiphospholipid syndrome (APS). We therefore compared single antiplatelet therapy and a combination of antiplatelet and anticoagulation therapy for secondary prevention in ischemic stroke patients with APS.The subjects were 20 ischemic stroke patients with antiphospholipid antib...

BACKGROUND Thrombotic antiphospholipid syndrome is defined as a complex form of thrombophilia that is developed by a fraction of antiphospholipid antibody (aPLA) carriers. Little is known about the genetic risk factors involved in thrombosis development among aPLA carriers. METHODS To identify new loci conferring susceptibility to thrombotic antiphospholipid syndrome, a two-stage genotyping s...