Oxidative stress has been associated with the onset and progression of mild cognitive impairment (MCI) and Alzheimer disease (AD). AD and MCI brain and plasma display extensive oxidative stress as indexed by protein oxidation, lipid peroxidation, free radical formation, DNA oxidation, and decreased antioxidants. The most abundant endogenous antioxidant, glutathione, plays a significant role in ...

INTRODUCTION The existence of hyperglycaemia produces increased oxidative stress. The depletion of antioxidants as a defensive body mechanism may increase the risk of diabetic complications. Diabetes mellitus is associated with derangements in the serum levels of several biochemical parameters, and type 2 diabetes mellitus (or non-insulin-dependent diabetes mellitus) is a risk factor for cardio...

Gastric ulcers have been considered as a major problem worldwide. This study investigated the protective synergistic effect of novel nutrient formulation for protection and treatment indomethacin-induced gastric ulcer in rat model. 24, 8 w old male rats with body weight between 220 240 g, were divided into four groups used this study. Group 1 consists healthy controls group 2 ulcerative animals...

OBJECTIVE This study examined the relationship between cellular glutathione and vitamin E concentrations and the effect of vitamin E (alpha-tocopherol) supplementation on glutathione and lipid peroxidation product concentrations in the erythrocytes of type 1 diabetic patients. RESEARCH DESIGN AND METHODS We obtained written informed consent to participate in this study from diabetic patients ...

Protective potential of propolis was evaluated against mercury induced oxidative stress and antioxidant enzymatic alterations in mice liver. Exposure to mercuric chloride (HgCl2; 5 mg/kg; ip) induced oxidative stress by increasing lipid peroxidation and oxidized glutathione level along with concomitant decrease in glutathione and various antioxidant enzymes. Mercury intoxication deviated the ac...

BACKGROUND Oxidative stress affects sperm quality negatively. To maintain the pro/antioxidant balance, some metal ions (e.g. copper, zink, iron, selenium), which are co-factors of the antioxidant enzymes, are essential. However, iron and copper could act as prooxidants inducing oxidative damage of spermatozoa. AIMS To reveal a possible correlation between the concentrations of some metal ions...

The assumption of oxidative stress as a mechanism in lead toxicity suggests that antioxidants might play a role in the treatment of lead poisoning. The present study was designed to investigate the efficacy of lipoic acid (LA) in rebalancing the increased prooxidant/antioxidant ratio in lead-exposed Chinese hamster ovary (CHO) cells and Fischer 344 rats. Furthermore, LA‘s ability to decrease le...

BACKGROUND: Osteoporosis is a condition of reduced bone mineral density (BMD) which leads to increased bone fragility and a marked increase in the risk of fractures. Postmenopausal osteoporosis affects women from one to twenty years after menopause. During these years, menopausal hormonal changes cause alterations in the serum levels of various biochemicals which reflect the bone losses. OBJECT...