Key words: anti-GBM antibodies; Goodpasture's dis-titre of 252 IU. Antineutrophil cytoplasmic antibodies (ANCA) (in house assay), rheumatoid factor, and ease; insulin-dependent diabetes mellitus; simultaneous presentation cryoglobulins were negative. A renal biopsy demonstrated a florid crescentic glomerulonephritis with all glomeruli involved. Immunofluorescence showed strongly positive IgG an...

Purpose: We report a patient with refractory scleritis effectively treated rituximab after ineffective, initial, conventional immunosuppressive therapy.Case summary: A 58-year-old woman no specific medical history presented recurrent of the right eye. Her uncorrected visual acuities in both eyes were 20/20, and blood test for cytoplasmic antineutrophil antibody (C-ANCA) was positive. Systemic s...

A 54-year-old Caucasian female was admitted for fevers, night sweats, decreased appetite, weight loss of 20 pounds in 1 month, diffuse rash, and purpuric lesions on her lower extremities. Physical examination revealed a diffuse maculopapular rash on the anterior chest and trunk and a palpable, 1-cm, inguinal lymph node. Initial laboratory studies revealed hemoglobin of 9.1 g/dL, hematocrit of 2...

Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) is a rare condition that can cause rapid renal failure. Treatment involves steroids and other immunosuppressive agents. Agents for induction include rituximab, cyclophosphamide, pulse dose avacopan.

OBJECTIVES Pentraxin 3 (PTX3), in common with myeloperoxidase and proteinase 3, is stored in human neutrophil granules and is expressed on apoptotic neutrophil surface. We therefore investigated the presence of anti-PTX3 autoantibodies (aAbs) in the sera of antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) patients. METHODS Presence of anti-PTX3 autoantibodies was analy...

Antineutrophil cytoplasmic antibodies (ANCA) are well known to be associated with several types of vasculitis, including pauci-immune crescentic glomerulonephritis, a form of rapid progressive glomerular nephritis (RPGN). ANCA vasculitis has also been reported after administration of propylthiouracil, hydralazine, cocaine (adulterated with levimasole), allopurinol, penicillamine and few other d...

Antineutrophil cytoplasmic antibodies (ANCAs) against myeloperoxidase (MPO), proteinase 3 (PR-3), lactoferrin (LF), cathepsin G (CG) and elastase (EL) were determined to investigate whether the presence of ANCAs is closely related to extra-articular manifestations in Japanese patients with rheumatoid arthritis (RA). Antibodies against MPO, PR-3, LF, CG and EL were determined in sera from 125 pa...

BACKGROUND Autosomal dominant polycystic kidney disease (ADPKD) is an inherited disorder that is characterized by the development of cysts in the kidneys and other organs. Urinary protein excretion is usually less than 1 g/day, and ADPKD is rarely associated with nephrotic syndrome or rapidly progressive glomerulonephritis (RPGN). To date, myeloperoxidase (MPO)-antineutrophil cytoplasmic antibo...

BACKGROUND Increasing evidence indicates that antineutrophil cytoplasmic antibody (ANCA)-positive conversion occurs in patients initially diagnosed with idiopathic pulmonary fibrosis (IPF) and as a result, some of these patients develop microscopic polyangiitis (MPA). However, the incidence density of these patients is not well known. OBJECTIVES To explore the incidence of ANCA-positive conve...

The optimization of immunosuppressive therapies has led to a marked improvement in the survival ANCA-associated vasculitides (AAV). main issue now appears be management comorbidities and quality life. objective this review was investigate incidence impact AAV-associated comorbidities, as well determinants health-related life (HRQoL). We performed systematic literature articles published Medline...