Cisplatin and other platinum derivatives are among the most effective chemotherapeutic agents against solid tumors including ovarian, head and neck carcinomas, and germ cell tumors. The major side effect of cisplatin is nephrotoxicity. While several antineoplastic agents frequently exhibit nephrotoxicity, the platinum derivatives are among the most frequent compounds leading to renal injury (1)...

PURPOSE Antineoplastic preparation presents unique safety concerns and consumes significant pharmacy staff time and costs. Robotic antineoplastic and adjuvant medication compounding may provide incremental safety and efficiency advantages compared with standard pharmacy practices. METHODS We conducted a direct observation trial in an academic medical center pharmacy to compare the effects of ...

OBJECTIVES Protease inhibitors are one of the most promising and investigated subjects for their role in pharmacognostical and pharmacological studies. This study aimed to investigate antineoplastic and antioxidant activity of trypsin inhibitors (TIs) isolated from three plant sources and their inhibitory role in the cell line. MATERIALS AND METHODOLOGY TIs were obtained from different plant ...

Farnesyltransferase (FTase) inhibitors (FTI) have broad antineoplastic actions targeting both cancer cells and mesenchymal cells involved in tumor angiogenesis. The small GTPases H-Ras, Rheb, and RhoB and the centromere proteins CENP-E and CENP-F are relevant targets of farnesylation inhibition; however, their relative importance in the antineoplastic effect of FTIs may vary in different cell t...

1,25-Dihydroxyvitamin D (calcitriol), the most active metabolite of vitamin D, has significant antineoplastic activity in preclinical models. Several mechanisms of activity have been proposed. These include inhibition of proliferation associated with cell cycle arrest and, in some models, differentiation, reduction in invasiveness and angiogenesis, and induction of apoptosis. Proposed mechanism...

Medicinal plants have duly been implicated in the development of typical antineoplastic agents. Here, medicinal plant under discourse, Trichosanthes dioica Roxb., commonly known as Pointed gourd English, Potol Bengali, is a climber vine found wild and cultivated all over plains India its neighbouring countries for fruits, consumed favoured vegetable. The present work attempts to assemble critic...

76. Connor TH, Anderson RW, Sessink PJ et al. Effective-ness of a closed-system device in containing surface contamination with cyclophosphamide and ifosfamidein an i.v. admixture area. Am J Health-Syst Pharm. 2002; 59:68–72.77. Vandenbroucke J, Robays H. How to protect environ-ment and employees against cytotoxic agents: the UZGent experience. J Oncol Pharm Pract. 2001;...

The aim was to research the pharmacotherapy of psoriasis with antiphospholipid syndrome based on ABC/VEN analysis antiviral drugs. materials study were clinical and pharmacological groups for background syndrome. Regulatory, documentary, marketing, pharmacoeconomic, methods used. Studied most drugs INN basic have diagnostic codes ATC classification L "Antineoplastic immunomodulatory agents" cod...