The aim of this study was to evaluate the mutagenicity (clastogenicity/aneugenicity) of a glycolic extract of Ziziphus joazeiro bark (GEZJ) by the micronucleus assay in mice bone marrow. Antimutagenic activity was also assessed using treatments associated with GEZJ and doxorubicin (DXR). Mice were evaluated 24-48 h after exposure to positive (N-nitroso-N-ethylurea, NEU - 50 mg.kg(-1) and DXR - ...

The Balkan region endemite Haberlea rhodopensis is a world record-holder in desiccation tolerance. Regarding the variable biological activities of Haberlea rhodopensis, it is important to study its antimutagenic activity in somatic cells in vivo. New Zealand white rabbits were intramuscular (i.m.) administered with total extract of HR at a dose of 100 mg/kg b. wt. for two consecutive days then ...

The review summarizes information from the literature on distribution, systematics, study of composition and biological activity metabolites, total extracts plants genus Agastache J.Clayton ex Gronov. To date, 22 species are known, most them endemic to North America. Only one – rugosa is grows in Asia Russian Far East. 7 this known be used ethnomedicine. In world's official medicine, not used, ...

This study was undertaken to understand how Lentinula edodes modulates in vivo mutagenesis induced by alkylating agents in bone marrow and peripheral blood as described in our previous article. Male Swiss mice were pretreated for 15 consecutive days with aqueous extracts prepared from L. edodes, after which, the number of circulating blood cells, normal erythroid bone marrow cell cycling, and p...

Nowadays kefir is one of trending topic in the world especially beverage topic. Kefir can be defined as a fermented milk drink made by actions bacteria and yeasts which are contained grains. has unique taste properties. In general, grains contain relatively stable specific microbiota enclosed matrix polysaccharides proteins, but populations individual seem to contribute characteristics present ...

ŠMERÁK P., ŠESTÁKOVÁ H., POLÍVKOVÁ Z., BÁRTA I., TUREK B., BÁRTOVÁ J., LANGOVÁ M., ANDĚL M. (2002): Antimutagenic effect of ellagic acid and its effect on the immune response in mice. Czech J. Food Sci., 20: 181–191. Using the Ames bacterial mutagenicity test and an in vivo micronucleus test, we investigated the antigenotoxic effect of ellagic acid on the genotoxicity of three mutagens: amino-m...

Total polyphenols content and a partial phenolics composition from pulp and peel of organically and conventionally produced Malus domestica, Annurca were investigated. Furthermore, the antimicrobial effect of these compounds against useful and pathogen microorganism was examined. Finally, their mutagenic activities were evaluated. Organically grown apples showed a greater content of polyphenols...