BACKGROUND O'Neill's recent Review on Antimicrobial Resistance expressed the view that by 2020 high-income countries should make it mandatory to support antimicrobial prescribing with rapid diagnostic evidence whenever possible. METHODS Routine microbiology diagnosis of 95 respiratory specimens from patients with severe infection were compared with those generated by the Unyvero P55 test, whi...

Many bacterial pathogens are becoming drug resistant faster than we can develop new antimicrobials. To address this threat in public health, a metamodel antimicrobial cocktail optimization (MACO) scheme is demonstrated for rapid screening of potent antibiotic cocktails using uropathogenic clinical isolates as model systems. With the MACO scheme, only 18 parallel trials were required to determin...

BACKGROUND Antimicrobial peptides are a promising alternative to conventional antibiotics. Plants are an important source of such peptides; their pharmacological properties are known since antiquity. Access to relevant information, however, is not straightforward, as there are practically no major repositories of experimentally validated and/or predicted plant antimicrobial peptides. PhytAMP is...

The aim of this study was to isolate β-haemolytic Aeromonas hydrophila strains from live rainbow trouts (Oncorhynchus mykiss) destined for human consumption and to investigate their resistance to antimicrobial drugs. Sterile swab samples were collected from 52 rainbow trouts. Fifteen (28.8%) βhaemolytic Aeromonas strains were isolated from collected 52 swab samples. Through API 20 NE, 12 of the...

Growth of Acinetobacter calcoaceticus on specific alkanes altered the outer membrane permeability of the organism, as indicated by a change in sensitivity to the antibiotic actinomycin D. As the carbon length of the alkane energy source decreased, outer membrane permeability and susceptibility to actinomycin D increased. Concomitant with the increase in outer membrane permeability, A. calcoacet...

BACKGROUND Pycnocycla spinosa (P. spinosa) a member of the Umbelliferae family is traditionally used for treatment of different ailments. OBJECTIVES This study aimed to evaluate the total phenolic and flavonoid content of P. spinosa extracts (methanol, ethanol and aqueous) and their antioxidant and antimicrobial effects. MATERIALS AND METHODS The antimicrobial activity of different extracts...

Objective: To evaluate the anticariogenic effect of dandelion extract against different oral pathogenic clinical isolates. Methods: In the present study, we evaluated the antimicrobial effect of dandelion against oral pathogens by the minimum inhibitory concentration and minimum bactericidal concentration. Clinical isolates such as Enterococcus faecalis, Streptococcus mutans, Streptococcus sali...

AIM This study was conducted to evaluate the incidence of clinical mastitis in bovines of Jammu region, to identify the infectious organisms responsible for it, and the antimicrobial sensitivity of isolated pathogens. MATERIALS AND METHODS The study was conducted on cases that were presented to the Medicine Division of Teaching Veterinary Clinical Complex, Faculty of Veterinary Sciences and A...

OBJECTIVE To evaluate the frequency and antimicrobial susceptibility pattern of Acinetobacter species isolated from pus and pus swab specimens at a tertiary care setting. STUDY DESIGN Cross-sectional observational study. PLACE AND DURATION OF STUDY Department of Microbiology, Armed Forces Institute of Pathology, Rawalpindi, from July 2008 to July 2012. METHODOLOGY Data regarding positive ...

Gonorrhoea is a major public health concern globally. Of particularly grave concern is that resistance to the extended-spectrum cephalosporins has emerged during the most recent years. This guideline provides recommendations regarding the diagnosis and treatment of gonorrhoea in Europe. Compared to the outdated 2009 European gonorrhoea guideline, this 2012 European gonorrhoea guideline provides...