Urinary tract infections (UTIs) are among the most common diagnosed in clinical practice. Treatment is often initiated before microbiological confirmation and anti-microbial susceptibility testing. With rapidly rising antibiotic resistance treatment failures not uncommon. Beta-lactamase production by gram-negative bacteria causing UTI commonest mode of drug resistance. The aim current study was...

Due to the ongoing concern about the reliability of Staphylococcus breakpoints (interpretive criteria) for other β-lactam agents, the Clinical and Laboratory Standards Institute recently approved the elimination of all breakpoints for antistaphylococcal β-lactams except for penicillin, oxacillin or cefoxitin, and ceftaroline. Routine testing of penicillin and oxacillin or cefoxitin should be us...

Background and Aims: Pseudomonas aeruginosa is an opportunistic pathogen. The appearance of the Metallo-β-Lactamases genes and their spread among bacterial pathogens is a matter of concern with regard to the future of antimicrobial therapy.Antimicrobial resistance is an innate feature of bacterial biofilms. Biofilm formation is higher in MDR strains. The present study was undertaken with the ai...

The retrospective study included 96 Serratia strains isolated from the patients hospitalized in the Clinical County Emergency Hospital Braşov during 2013. The objectives consisted in the evaluation of frequency and distribution of Serratia species in the hospital departments, in analysing the infections in which this germs were implicated and determination of antimicrobial resistance of the iso...

background: multidrug resistance and production of extended spectrum β-lactamases (esbls) by enteric gram-negative rods in hospitals and community continue to be worsened. we aimed to characterize the multidrug resistance and determine the prevalence of esbl production by clinical isolates of enterobacteriaceae in southeast iran.   methods: gram-negative bacteria isolated from clinical samples ...

few novel cobalt(ii) and copper(ii) complexes [m(fmp)3]cl2, [m(fmp)(bpy)2]cl2,[m(fmp)(phen)2]cl2 and [m(fmp)(phen)(bpy)]cl2 (fmp = 3-furan-2-ylmethylene-pentane-2,4-dione, phen = 1,10-phenanthroline, bpy = 2,2'-bipyridine) have been synthesized andcharacterized by elemental analyses, molar conductance, magnetic susceptibility measurements,ir, electronic, epr, mass spectra and cyclic voltam...

OBJECTIVES Antimicrobial stewardship programs are recommended to reduce antimicrobial resistance by reducing inappropriate use of antimicrobials. We implemented an antimicrobial stewardship program and aimed to evaluate its effect on broad-spectrum antimicrobial use. DESIGN, SETTING AND PARTICIPANTS Observational study with historical control using interrupted time series analysis conducted i...

AmpC β-lactamase enzymes confer resistance to a wide variety of β-lactam antibiotics, except carbapenems. AmpC β-lactamase-producing bacteria are known to be causative pathogens of nosocomial infections, which are difficult to be treated. Hence, this study was aimed out to determine the prevalence of AmpC β-lactamase enzyme production among Gram-negative bacteria. A total of 500 multidrug-resis...

Roseomonas are described as opportunistic pathogens rarely involved in human infections. Their identification requires molecular methods and their antimicrobial susceptibility pattern varies according to the species. We report the first case of bacteremia due to Roseomonas mucosa in a child with leukemia and reviewed pediatric cases of Roseomonas infection, for which undoubted strain identifica...

As part of the Tigecycline Evaluation and Surveillance Trial (T.E.S.T) we report the in vitro activity of tigecycline and its comparators against Gram-negative and Gram-positive organisms collected from Italian centers between 2012 and 2014. Minimum inhibitory concentrations were determined according to the broth microdilution methodology of the Clinical and Laboratory Standards Institute, and ...