The purpose of this study is to carry out comparative in vitro study of bactericidal effect of antimicrobial drugs used in modern endodontics against some basic microbial agents of periodontitis. Using the agar diffusion method (experiment with sterilized disks and wells) antimicrobial effect of five antimicrobial agents used in endodontics is evaluated: Rockle, Cresophene, I2/KI, Cupral, Ca(OH...

Antimicrobial peptides constitute a diverse class of naturally occurring antimicrobial molecules which have activity against a wide range of pathogenic microorganisms. Antimicrobial peptides are exciting leads in the development of novel biocidal agents at a time when classical antibiotics are under intense pressure from emerging resistance, and the global industry in antibiotic research and de...

A number of surveillance studies have been conducted looking for organisms with decreased susceptibility to antimicrobial agents in natural environments. There was no evidence of shifts in populations or development of resistance to the antimicrobial agents in any of these studies. Nor was there any evidence of a correlation of resistance between antimicrobial-tolerant strains and antibiotic re...

BACKGROUND Increasing antimicrobial resistance has been identified as an important global health threat. Antimicrobial use is a major driver of resistance, especially in the hospital sector. Understanding the extent and type of antimicrobial use in Canadian hospitals will aid in developing national antimicrobial stewardship priorities. METHODS In 2002 and 2009, as part of one-day prevalence s...

The use of antimicrobial agents in humans and food-producing animals has important consequences for human and animal health, as it can lead to the development of resistant bacteria (pathogens and/or commensals with resistance genes). Moreover, resistant bacteria in animals can be transferred to people--usually through the consumption of food, but also through direct contact with food-producing ...

The minimal inhibitory concentrations (MICs) of 23 Treponema phagedenis-like spirochetes isolated from dairy cattle with papillomatous digital dermatitis (PDD) lesions in Japan were investigated by a broth microdilution method using 15 antimicrobial agents. Although all MIC values showed a monomodal distribution, the MICs of the antimicrobial agents for 90% (MIC(90)) of the isolates tested vari...

BACKGROUND The development of antimicrobial guidelines is one way in which institutions attempt to control emerging resistance, but the real challenge falls on promoting and ensuring adherence to these guidelines. Investigating reasons for the prescribing of alternative antimicrobial agents outside of these guidelines is crucial for modifying practices that may adversely impact institutional an...

The use of antimicrobial agents in aquaculture can lead to both direct and indirect effects, as a result of the response of an organism to the presence of the agent. These effects can be considered in terms of the risks associated with toxicity linked to residues in human food, the development of resistance following antimicrobial therapy or the potential for environmental consequences. There i...

BACKGROUND In response to concerns of bacterial biofilm colonization of dental unit waterlines, a wide range of commercial intermittent and continuous chemical treatments for dental unit waterlines have been developed and marketed. There has been little research on the possible effect of continuous chemical treatment regimens on dentin-bonding agents. The authors evaluate the effect of four pro...

Pharmacodynamics describes the relationship between measures of drug levels in serum and tissue fluids and the antimicrobial and toxicologic effects of drugs (5, 10, 17, 49). While there have been numerous studies describing the pharmacokinetics of fluoroquinolones in serum and tissues, there has been much less emphasis on describing the time course of antimicrobial activity with these drugs. T...