Plant derived oils have recently been found to be more effective in pharmaceutical sectors than synthetic goods since these plants contain physiologically active chemicals with a wide range of therapeutic effects. Essential oil, also known as essence, volatile etheric or aetheroleum, is complex mixture elements biosynthesised by living organisms, which particularly abundant aromatic plants. Thi...

The in vitro antimalarial activity against Plasmodium falciparum K1 of the four extracts from the stembark of Picrasma javanica Bl, that is, water, methanol, chloroform and hexane were studied using a modification of the [ 3 H]hypoxanthine incorporation method. It was found the chloroform extract showed in vitro antimalarial activity with IC50 of 20.0 g/ml. The extract was further isolated usi...

important class of naturally occurring compounds. They are found in plants, fungi and bacteria. These compounds are aromatic rings with two ketone substitutions. Large number of quinones has been associated with antitumor, antibacterial, antimalarial and antifungal activities. The antitumor activity is exhibited predominantly by three main groups of naturally occurring quinones such as benzoqui...

Malaria is a protozoal disease transmitted by the Anopheles mosquito, caused by minute parasitic protozoa of the genus Plasmodium, which infect human and insect hosts alternatively. It affects over 40% of the worldís population, with 120 million cases reported, and about 2 million deaths annually (1). The P. falciparum variety of the parasite accounts for 80% of cases and 90% of deaths caused b...

8-Aminoquinoline (8AQ) derivatives have been reported to have antimalarial, anticancer, and antioxidant activities. This study investigated the potency of 8AQ-5-substituted (iodo and nitro) uracils metal (Mn, Cu, Ni) complexes (1-6) as antimalarial and antimicrobial agents. Interestingly, all of these metal complexes (1-6) showed fair antimalarial activities. Moreover, Cu complexes 2 (8AQ-Cu-5I...

Malaria is one of the top health problems in Yemen. This study was done to evaluate the availabilit and prescribing of antimalarial drugs in Al-Mukalla city, based on the treatment guidelines of the National Malari Control Programme (NMCP). Chloroquine, quinine and sulfadoxine/pyrimethamine were the most availabl and prescribed antimalarial drugs in all 60 pharmacies (government and private) in...

Despite the urgent need for effective antimalarial drugs with novel modes of action no new chemical class of antimalarial drug has been approved for use since 1996. To address this, we have used a rational approach to investigate compounds comprising the primary benzene sulfonamide fragment as a potential new antimalarial chemotype. We report the in vitro activity against Plasmodium falciparum ...

Malaria, known as the "fevers," has been treated for over three thousand years in China with extracts of plants of the genus Artemisia (including Artemisia annua, A. opiacea, and A. lancea) from which the active compound is artemisin, a sesquiterpene that is highly effective in the treatment of the disease, especially against young forms of the parasite. South American Indians in the seventeent...

The development of resistance by Plasmodium falciparum to conventional drugs poses a threat to malaria control. There is therefore a need to find new, effective, and affordable remedies for malaria, including those derived from plants. This study demonstrates that crude, reverse-phase high-pressure liquid chromatography (RP-HPLC)-semipurified, and RP-HPLC-purified root extracts of Fagara zantho...