نتایج جستجو برای: antimalarial agents
تعداد نتایج: 366169 فیلتر نتایج به سال:
Dihydroorotate dehydrogenase (DHODH) is an enzyme necessary for pyrimidine biosynthesis in protozoan parasites of the genus Plasmodium, the causative agents of malaria. We recently reported the identification of novel compounds derived from diversity-oriented synthesis with activity in multiple stages of the malaria parasite life cycle. Here, we report the optimization of a potent series of ant...
New drugs against malaria are greatly needed. Many approaches to antimalarial drug discovery are available. These approaches must take into account specific concerns, in particular the requirement for very inexpensive and simple to use new therapies and the need to limit the cost of drug discovery. Among important efforts that are currently ongoing are the optimization of therapy with available...
Several kalihinol natural products, members of the broader isocyanoterpene family of antimalarial agents, are potent inhibitors of Plasmodium falciparum, the agent of the most severe form of human malaria. Our previous total synthesis of kalihinol B provided a blueprint to generate many analogues within this family, some as complex as the natural product and some much simplified and easier to a...
Although the antimalarial agent artemisinin itself is not active against tuberculosis, conjugation to a mycobacterial-specific siderophore (microbial iron chelator) analogue induces significant and selective antituberculosis activity, including activity against multi- and extensively drug-resistant strains of Mycobacterium tuberculosis. The conjugate also retains potent antimalarial activity. P...
background & aim: antiplasmodial activity of leaf extract of breynia nivosa was evaluated to ascertain the folkloric claim of its antimalarial activity. experimental: the crude leaf extract (75 – 225 mg/kg), of breynia nivosa was investigated for antiplasmodial activity against chloroquine sensitive plasmodium berghei infections in mice. the antiplasmodial activity during early and establis...
as powerful antimalarial agents. The work carried out in the School of Tropical Medicine, Calcutta, on the action of these drugs on the Indian strains of malaria parasites is in accord with findings obtained in other parts of the world. Plasmoquin has been tried by a large number of workers, and in India, Napier, Butcher and Das Gupta (1932) used it with success in their field experiments. Ateb...
Plasmodium falciparum resistance to artemisinin derivatives, the first-line antimalarial drug, drives the search for new classes of chemotherapeutic agents. Current discovery is primarily directed against the intracellular forms of the parasite. However, late schizont-infected red blood cells (RBCs) may still rupture and cause disease by sequestration; consequently targeting invasion may reduce...
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