objective(s):solanum acueastrum dunal.has been shown to have some chemotherapeutic value. leaf and berry water and methanol compounds of s. acueastrum were evaluated for possible antileishmanial activity in vivo on balb/c mice and in vitro against leishmania major promastigotes, amastigotes and vero cells.  materials and methods: dry s. aculeastrum berry and leaf material were extracted in meth...

BACKGROUND Plants have served either as a natural templates for the development of new chemicals or a phytomedicine since antiquity. Therefore, the present study was aimed to appraise the polarity directed antioxidant, cytotoxic, protein kinase inhibitory, antileishmanial and glucose modulatory attributes of a Himalayan medicinal plant- Quercus dilatata. METHODS Total phenolic and flavonoid c...

1,3,4-Thiadiazole skeleton forms an integral part of various medicinal agents and depicts a vast array of biological activities such as antimicrobial, anti-inflammatory, analgesic, antileishmanial, antitumor, anti-tuberculosis, antileptic, antiviral and other activities. 1,3,4-Thiadiazole moiety has many desirable features which makes them pharmaceutically suitable as it can act as “hydrogen bi...

Current therapy for leishmaniasis is not satisfactory. We describe the in vitro antiproliferative effects of new thiadiazine derivatives against Leishmania amazonensis. The compounds were found to be active against the amastigote form of the parasite, inhibiting parasite growing, from 10 to 89%, at a concentration of 100 ng/ml. This activity suggests that thiadiazine derivatives could be consid...

Low oxygen environments and accumulation of hypoxia-inducible factors (HIFs) are features of infected and inflamed tissues. Here, we summarize our current knowledge on oxygen levels found in Leishmania-infected tissues and discuss which mechanisms potentially contribute to local tissue oxygenation in leishmanial lesions. Moreover, we review the role of hypoxia and HIF-1 on innate antileishmania...