The incidence of diabetes mellitus is skyrocketing in sub-Saharan Africa and the world at large, with about 8.8% adult population currently affected projected to rise 9.9% by year 2045. used drugs are beset serious side effects, reduced efficacy due prolonged use high cost. This study therefore aimed exploring medicinal plants for development cheaper more effective herbal remedies/plant-derived...

Among a number of classes of oral antihyperglycemic drugs, sulfonylureas (SUs) demonstrating the potential effect to reduce blood glucose level have been used in a majority of patients with type 2 diabetes for many years. The pathophysiological processes by which SUs adversely induce the risk of cardiovascular disease have not been fully clarified. We summarized about the relationship between S...

An interim update of the chapter titled Pharmacologic Management of Type 2 Diabetes in the 2013 Clinical Practice Guidelines was recently published in Canadian Journal of Diabetes; it incorporates the sodium glucose linked transporter 2 (SGLT2) inhibitor class (1). Since the publication of the update, another SGLT2 inhibitor has received notice of compliance from Health Canada (2). The article’...

The quinoline core structure is an important heterocyclic feature that can be found in numerous biologically active componds which exhibit a vast range of pharmacological properties such as antimalarial [1], antibacterial [2], antimicrobial [3], and antistaphylococcal activities [4]. Meanwhile, an important class of antibiotics possesses a 4-quinolone framework in their structure [5], and also ...