Plants produce potent constitutive and induced antifungal compounds to complement the structural barriers to microbial infection. Approximately 250,000-500,000 plant species exist, but only a few of these have been investigated for antimicrobial activity. Nevertheless, a wide spectrum of compound classes have been purified and found to have antifungal properties. The commercial potential of eff...

This Special Issue is designed to highlight the latest research and development on new antifungal compounds with mechanisms of action different from the ones of polyenes, azoles, and echinocandins. The papers presented here highlight new pathways and targets that could be exploited for the future development of new antifungal agents to be used alone or in combination with existing antifungals. ...

the synthesis, characterization and application of biologically synthesized nanomaterials are an important aspect in nanotechnology. the present study deals with the synthesis of silver nanoparticles (ag-nps) using the aqueous extract of red seaweed gelidiella acerosa as the reducing agent to study the antifungal activity. the formation of ag-nps was confirmed by uv-visible spectroscopy, x-ray ...

Recent studies suggest that antifungal resistance in yeast isolates of veterinary origin may be an underdiagnosed threat. We tested a collection of 92 ascomycetous yeast isolates that were obtained in Spain from birds, mammals and insects for antifungal susceptibility. MICs to amphotericin B and azoles were low, and no resistant isolates were detected. Despite these results, and given the poten...

Fatty acids are widely occurring in natural fats and dietary oils and they are known to have antibacterial and antifungal properties. However, little is known on the antibacterial and antifungal properties of the blindyour-eye mangrove (Excoecaria agallocha) and this study for the first time determines the fatty acid composition and the antibacterial and antifungal activities of Fatty Acid Meth...

This Special Issue is designed to highlight the latest research and development on new antifungal compounds with mechanisms of action different from the ones of polyenes, azoles, and echinocandins. The papers presented here highlight new pathways and targets that could be exploited for the future development of new antifungal agents to be used alone or in combination with existing antifungals. ...

Invasive fungal infections are associated with significant morbidity and mortality despite advances in medical care. Aggressive diagnostic approaches in “at risk” patients, coupled with prompt antifungal therapy, are essential for patient survival. Early intervention is strongly recommended, rather than waiting for microbiological or histopathological confirmation. The selection of antifungal a...

The activities of a series of camptothecin and nitidine derivatives that might interact with topoisomerase I were compared against yeast and cancer cell lines. Our findings reveal that structural modifications to camptothecin derivatives have profound effects on the topoisomerase I-drug poison complex in cells. Although the water-soluble anticancer agents topotecan and irinotecan are less activ...

The structures of atpenins A4, A5 and B, new antifungal antibiotics produced by Penicillium sp., have been deduced to be I, II and III, respectively, on the basis of spectroscopic and 1H and 13C NMR spectral data. The molecular structure of atpenin A4 with absolute configurations was finally confirmed to be 2'S,4'S,5'S-5,6-dimethoxy-4-hydroxy-5'-chloro-2',4'- dimethyl-1'-oxoheptyl-2-hydroxypyri...

In a recent Editorial on the role of antifungal treatment in hematology, Maertens et al. analyzed the diagnostic and therapeutic antifungal strategies which are used in particular in neutropenic patients. Among the various topics covered, some observations concerned antifungal prophylaxis. They underlined some critical issues of antifungal prophylaxis including the lack of evidence of its impac...