Classical amnesia involves a difficulty in transferring information to long-term memory and can be detected with standard clinical tests. However, there are some patients who pass these tests but nonetheless show longer-term memory impairments. A case study is presented of a patient, RY, with temporal lobe epilepsy, who exhibited such a profile of "accelerated long-term forgetting". To investig...

About 20-30% of patients with epilepsy continue to have seizures despite carefully monitored treatment with antiepileptic drugs. The mechanisms explaining why some patients' respond and others prove resistant to antiepileptic drugs are poorly understood. It has been proposed that pharmacoresistance is related to reduced sensitivity of sodium channels in hippocampal neurons to antiepileptic drug...

We report a patient with abnormal saccades in association with anticonvulsant toxicity (phenytoin 27.5 micrograms/ml, phenobarbital 18.8 micrograms/ml). The patient looked toward visual targets either with multiple, small, hypometric saccades or with single slow saccades. These abnormalities resolved when anticonvulsant levels returned to therapeutic range. Thus, slow saccades may be clinical e...

Oxidative stress has been suggested as a consequence and as a cause of epileptic seizures. Researches indicate Achillea wilhelmsii (A.wilhelmsii) has anti-oxidant and anti-spasmic effects on central nervous system. This plant grows in most part of Iran. An Iranian research that done in 2013 showed that the hydroalcoholic extract of Achillea wilhelmsii possesses an antioxidant effect in the brai...

In our previous studies we have reported the CNS activities of the synthesised heterocyclic ring compounds (1,2). Certain phenylurethanes of pyrazolidinols and piperidazinols have moderate anticonvulsant activity (3). Some 2-(N-substituted glycylamino)-methylthiazoles and (l-phenyl-l-hydroxycthyl) azoles have been found to possess, anticonvulsant and anxiolytic activities (4,5). A series of 5-a...

WHAT IS KNOWN AND OBJECTIVE Antiepileptic drugs often produce serious adverse effects, and many patients do not respond to them properly. Phytocannabinoids produce anticonvulsant effects in preclinical and preliminary human studies, and appear to produce fewer adverse effects than available antiepileptic drugs. The present review summarizes studies on the anticonvulsant properties of phytocanna...

Phenytoin is an anticonvulsant agent of the first-generation that blocks voltage-gated Na -channels. Systemic administration of phenytoin induces anticonvulsant effect in humans and in experimental animals. Moreover, it was demonstrated that this drug also inhibited neuropathic and post-stroke pain. The present study was undertaken in order to determine the effect of a direct phenytoin administ...

BACKGROUND AND PURPOSE Midazolam is a short-acting benzodiazepine that is widely used as an i.v. sedative and anticonvulsant. Besides interacting with the benzodiazepine site associated with GABA(A) receptors, some benzodiazepines act as agonists of translocator protein (18 kDa) (TSPO) to enhance the synthesis of steroids, including neurosteroids with positive modulatory actions on GABA(A) rece...

the fruit essential oil of ferula gummosa boiss., umbelliferae, which has been used as an antiepileptic remedy in iranian traditional medicine, was evaluated for anticonvulsant activity against experimental seizures. the essential oil had no effect against seizures induced by maximal electroshock. however, it protected mice against pentylenetetrazole-induced tonic seizures. the protective dose ...

Objective(s): Cognitive deficit is a common problem in epilepsy. A major concern emergent from the use of antiepileptic drugs includes their side effects on learning and memory. Herbal medicine is considered a complementary and alternative therapy in epilepsy. Apigenin is a safe flavone with antioxidant properties. However, there is little information about the benefic...