The naïve antibody/B-cell receptor (BCR) repertoires of different individuals ought to exhibit significant functional commonality, given that most pathogens trigger an effective antibody response immunodominant epitopes. Sequence-based repertoire analysis has so far offered little evidence for this phenomenon. For example, a recent study estimated the number shared (‘public’) clonotypes in circ...

  An inactivated agalactia vaccine was prepared with Mycoplasma agalactiae in fermenter. The culture was inactivated and subsequently adjuvanted with aluminum hydroxide gel. Four sheep and four goats were immunized with the experimental vaccine. Two doses of 1ml of vaccine were administered three weeks interval. Monthly, blood samples were taken from the vaccinated animals up to the fifth month...