background and aims: the aim of this study was to determine the virulence and antibiotic resistance properties of streptococcus agalactiae (s. agalactiae) and streptococcus uberis (s. uberis) isolated from the ruminant’s sub-clinical mastitic milk in iran. materials and methods: positive samples in the cmt test were cultured and s. agalactiae and s. uberis have been identified using biochemical...

It has been said that when treating acute osteomyelitis, in this the era of antibiotic-resistant bacteria, the antibiotic given to the patient when first seen is usually chosen by "inspired" guesswork (Mercer, 1964). If an antibiotic were available to which all commonly encountered pathogens were sensitive then this guesswork would be eliminated. It would be unnecessary to change an antibiotic ...

The rampant spread of antibiotic resistant bacteria has spurred interest in alternative strategies for developing next-generation antibacterial therapies. As such, there has been growing interest in cationic antimicrobial peptides (CAMPs) and their therapeutic applications. Modification of CAMPs via conjugation to auxiliary compounds, including small molecule drugs, is a new approach to develop...

Alternative herbal medicine has been used to treat various infections from centuries. Natural plants contain phytoconstituents having similar chemical properties as of synthetic antibiotics. Typhoid fever is a serious infection and failure of its treatment emerged multi-drug resistant (MDR) bugs of Salmonella typhi. Due to multiple and repeated issues with antibiotics efficacy, it became essent...

For centuries, phytochemicals have been used to prevent and cure multiple health ailments. Phytochemicals have been reported to have antioxidant, antidiabetic, antitussive, antiparasitic, anticancer, and antimicrobial properties. Generally, the therapeutic use of phytochemicals is based on tradition or word of mouth with few evidence-based studies. Moreover, molecular level interactions or mole...

The mechanism by which ristocetin induces platelet agglutination in the presence of the von Willebrand factor was studied by chemically altering ristocetin and a similar antibiotic, vancomycin, by reaction with a water-soluble carbodiimide in the presence of glycine methyl ester at pH 4.75. Altering ristocetin's phenolic groups (which are thought to be important in its peptide-binding propertie...