Escherichia coli is among the most frequently encountered germs of purulent septic infections of various localizations. The E.coli strains tend to develop multiple resistance caused by the production of extended spectrum beta-lactamases (ESBLs) and carbapenemases. This dictates the necessity to search for new antimicrobial agents. In this respect, metal nanoparticles are promising candidates fo...

Determining the susceptibility of pathogens to antibacterial substances is one key steps in bacteriological diagnostics that affects success both therapeutic therapy and appropriate selection cosmetic products. Antibiotic chemotherapeutic sensitivity tests determine ability an antimicrobial agent inhibit growth a microorganism vitro.

In this study, the ability of porous silicon nanoparticles (PSi NPs) to entrap and deliver nitric oxide (NO) as an effective antibacterial agent is tested against different Gram-positive and Gram-negative bacteria. NO was entrapped inside PSi NPs functionalized by means of the thermal hydrocarbonization (THC) process. Subsequent reduction of nitrite in the presence of d-glucose led to the produ...

Ficus carica L. (fig) belongs to the mulberry tree (Moraceae) which is one of the oldest fruits in the world. It has been used as a digestion promoter and a cure for ulcerative inflammation and eruption in Korea. The present study investigated the antimicrobial activity of methanol (MeOH) extract of figs against oral bacteria. The MeOH extract (MICs, 0.156 to 5 mg/ml; MBCs, 0.313 to 5 mg/ml) sh...

Preliminary differentiating screening of the antibacterial and antifungal activity of a series of diastereomeric cis/trans-3-aryl(heteroaryl)-3,4-dihydroisocoumarin-4-carboxylic acids (3a-i) was performed by the agar diffusion method against twelve microorganism strains of different taxonomic groups. S. aureus and A. niger were the most sensitive strains to the antibiotic effect of the tested c...

The rhizomes of Alpinia pahangensis Ridley yielded a new bis-labdanic diterpene for which the name pahangensin A (1) was proposed along with a new labdane diterpene, pahangensin B (2). Their structures were elucidated by spectroscopic methods including, 1D and 2D NMR techniques and LCMS-IT-TOF analysis. Pahangensin A (1) was found to be an antibacterial agent against Staphylococcus aureus, Baci...

Chemerin, a chemoattractant ligand for chemokine-like receptor 1 (CMKLR1) is predicted to share similar tertiary structure with antibacterial cathelicidins. Recombinant chemerin has antimicrobial activity. Here we show that endogenous chemerin is abundant in human epidermis, and that inhibition of bacteria growth by exudates from organ cultures of primary human skin keratinocytes is largely che...

The morphology and anti bacterial activity of capped Silver Nanoparticles of 5-Methyl 2-mercapto benzimidazole prepared via chemical reduction is studied. Spherical shaped capped Ag-NPs with size of 40nm are obtained by treatment of aqueous silver ions with ethanolic solution of 5-Methyl 2-mercapto benzimidazole as capping agent .The synthesized nanoparticles are characterized by SEM, TEM, XRD,...

A new method of assessing the bactericidal activity of quinolones and other antibacterial agents, known as the bactericidal index or BI, is introduced and discussed. The BI represents total bacterial kill over a drug concentration range limited to levels achievable in vivo. This method allows the bactericidal activity of drugs to be readily compared. Calculation of BI produces a single value pe...

Results. Male gender was a significant (P = 0.011) risk factor for acquiring otitis media (male Vs female; 36.25% Vs 25.38%. OR = 1.671 95 CI = 1.139, 2.454). Age significantly (P < 0.0001) affected the prevalence of otitis media with children within the age range of 0 – 5years having the highest prevalence of 78.41%. Pseudomonas aeruginosa was the predominant bacteria isolate causing otitis me...