OBJECTIVE To investigate the suitability of citrus-press cakes, by-products of the juice industry as a source for the whitening agents for cosmetic industry. METHODS Ethylacetate extracts of citrus-press cakes (CCE) were examined for their anti-melanogenic potentials in terms of the inhibition of melanin production and mechanisim of melanogenesis by using Western Blot analysis with tyrosinese...

Camellia tenuifloria is an indigenous Camellia species used for the production of camellia oil in Taiwan. This study investigated for the first time the potential antioxidant, anti-tyrosinase and anti-inflammatory activities of oil production byproducts, specifically those of the fruit shell, seed shell, and seed pomace from C. tenuifloria. It was found that the crude ethanol extract of the see...

Abstract Despite the richness and biodiversity of invertebrates algae in Mediterranean Sea, these organisms are still poorly studied. The objective our research is discovery bioactive lead compounds from Sea sponge Hemimycale Collumella (HC). HC (189.0 g) was collected Mdiq costs on extracted with methanol to yield (10 which then subjected fractionation. A bio-guided protocol applied through ev...

Retinoic acid (RA) is a hormone-like agent involved in the control of cell differentiation. The most characteristic feature of melanocyte differentiation, melanogenesis, is stimulated by UV radiations. Excessive chronic sun exposure results in irregular skin hypermelanosis that can be partially corrected by topical RA. The basic mechanisms underlying this effect of RA are unknown. To determine ...

In this work, a series of anti-tyrosinase and anti-butyrylcholinesterase coumarin derivatives 4a–f 5a–f were synthesized starting from 4-hydroxycoumarin. The condensation 2-(arylimin)-4-hydroxycoumarins 3a–f with dimethylformamide dimethyl acetal (DMF-DMA), used as key reaction, afforded the precursors 4a–f, whose acid treatment led to formation 5a–f. These prepared heterocycles characterized b...

Pigmentation has become an important phenotypical characteristic, in the pharmaceutical, medicinal as well as in the cosmetic field. Plants and their extracts are inexpensive and rich resources of active compounds that can be utilized to inhibit tyrosinase activity as well as melanin production. Natural and synthetic chemical agents can frequently modulate the metabolism of pigmentation produce...

Nowadays herbal medicines of skin-whitening cosmetics are popular with women. We attempted to find the whitening activity compounds present in many herbal medicines used for this purpose and discuss their mechanisms in melanin biosynthesis. The 70% acetone extracts of 10 kinds of herbs were investigated for their mushroom tyrosinase activity inhibition. Among these 10 extracts, Chinese galls sh...

Skin pigmentation disorders refer to conditions that affect the color of skin due alterations in production or distribution melanin, pigment responsible for color. The development is a complex process involving various signaling pathways, including melanin synthesis pathway, cyclic AMP and Wnt pathway. Dysregulation these pathways can lead disorders. Phytotherapeutic approaches have been increa...

Previously, we reported that acetaminophen (APAP) showed selective toxicity towards melanoma cell lines. In the current study, we investigated further the role of tyrosinase in APAP toxicity in SK-MEL-28 melanoma cells in the presence of a short hairpin RNA (shRNA) plasmid, silencing tyrosinase gene. Results from tyrosinase shRNA experiments showed that APAP led to negligible toxicity in shRNA ...