Dear Sir In the recently published Task force report, under section ‘Fibrinolytic regimens’, the authors recommend not to readminister streptokinase for at least 10 years. The reference supporting this statement is Ref. 51. After evaluating this paper and looking into the literature my comments are as follows: The referenced publication only contains data up to 7.5 years. In so far any comment ...

BACKGROUND Clinical spectrum, microbiology and outcome of empyema thoracis are changing. Intrapleural instillation of fibrinolytic agents is being increasingly used for management of empyema thoracis. The present study was carried out to describe the clinical profile and outcome of patients with empyema thoracis including those with chronic empyema and to study the efficacy and safety of intrap...

BACKGROUND The effects of alteplase (rtPA), streptokinase, and staphylokinase (rSak) on focal cerebral ischemia (FCI) and on pulmonary clot lysis (PCL) were studied in hamsters. METHODS AND RESULTS ++FCI was produced by ligation of the left middle cerebral artery (MCA) and common carotid artery (CCA) and a 10-minute occlusion of the right CCA. FCI was measured after 24 hours by 2,3, 5-triphen...

A mitogenic substance on murine lymphocytes was detected in the culture supernate of Streptococcus pyogenes type 12 strain. This substance had a molecular weight of 28,000 and pI 9.2, and was designated as S. pyogenes mitogen (SPM). The proliferative response of C3H/HeN spleen cells began at 1 ng ml-1 and reached a maximal response at 100 ng ml-1 of SPM for 4 days culture. Anti-Thy 1.2 mAb and ...

introduction group a β-hemolytic streptococcus is the most common cause of bacterial pharyngitis among 5 - 15-year-old children, but it is uncommon in children less than three years old and rarely happens in infants less than one year old. case presentation the patient was a 62-day-old female infant who presented with fever and poor feeding since two days before admission. at the time of admiss...

OBJECTIVES To study the clinical significance of infarct location during long term follow up in a trial comparing thrombolysis with primary angioplasty. DESIGN Retrospective longitudinal cohort analysis of prospectively entered data. SETTING Patients with acute ST elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI). PATIENTS In the Zwolle ...

The occurrence of ventricular arrhythmias attributed to streptokinase treatment in acute myocardial infarction is not well defined. Holter monitoring was performed for 24 hours in 81 patients with suspected acute myocardial infarction randomised in a ratio of 2:1 to intravenous streptokinase 1.5 x 10(6) IU (n = 55) or placebo infusion (n = 26) 6.7 hours (mean) after the onset of symptoms. No ep...

Methods are described for measuring plasminogen levels in human plasma and for studying plasmin generation in plasma with plasminogen activators. In plasma samples from two individuals with histories of deep vein thrombosis, the functional plasminogen values were determined to be below the normal range of 16.7 to 23.8 mg/lOO ml (average of 21.0 mg/lOO ml), and the plasmin generation rates were ...

We propose that psoriasis is a sequela of streptococcal infection similar to acute rheumatic fever (ARF). This hypothesis arises from many different lines of evidence: a markedly elevated serum anti-streptococcal antibody is present in plaque psoriasis. However, cultures are routinely negative in psoriasis because the Group A Streptococcus pyogenes “hides” inside cells and inside biofilms and i...

Streptokinase is a novel fibrionotic protein produced by several bacterial species. As a therapeutic, streptokinase can be used as thromboembolic disorders where it dissolves a blood clot by the activation of plasminogen to plasmin. In the present study, Bacillus licheniformis used for the production of streptokinase under soya bean as carbon source. The optimum day, pH and temperature were als...