We examined alternative and classical complement activation induced by whole bacilli of Mycobacterium bovis BCG and Mycobacterium tuberculosis products. After exposure to BCG, there were higher levels of the terminal complement complex in sera from Indian tuberculosis patients than in sera from healthy controls. The addition of BCG with or without EGTA to these sera indicated that approximately...

Abstrak : Tuberkulosis Paru Dengan Diabetes Mellitus Tipe 2 Setelah Menyelesaikan Terapi Anti 9 Bulan: Laporan Kasus. (TB) adalah penyakit menular yang disebabkan oleh bakteri Mycobacterium tuberculosis. Sebagian besar tuberculosis menyerang paru-paru menyebabkan TB paru, tetapi dapat juga organ tubuh lainnya. Lima dari 8 negara dengan insiden tertinggi termasuk di antara 10 prevalensi DM terti...

The appearance of drug-resistant strains of Mycobacterium tuberculosis (Mtb) poses a great challenge to the development of novel treatment programmes to combat tuberculosis. Since innovative nanotechnologies might alleviate the limitations of current therapies, we have designed a new nanoformulation for use as an anti-TB drug delivery system. It consists of incorporating mycobacterial cell wall...

Treatment of tuberculosis (TB) is a challenge because of multidrug-resistant and extremely drug-resistant strains of Mycobacterium tuberculosis. Plant species contain antimicrobial compounds that may lead to new anti-TB drugs. Previous screening of some tree species from the Anacardiaceae family revealed the presence of antimicrobial activity, justifying further investigations. Leaf extracts of...

background and objectives: resistance in mycobacterium tuberculosis is caused by mutations in genes encoding drug targets. investigators have already demonstrated the existence of mutations in codons 88 to 94 in the gyra gene and also in codons 1400, 1401, and 1483 of rrs gene among extensively and extremely drug resistant tuberculosis (xdr & xxdr-tb) strains. the aim of this study was to ident...

Bu çalışmada, önemli ekonomik kayıplara neden olan kronik enfeksiyöz bir hastalık Mycobacterium avium subsp. paratuberculosis (MAP) tarafından oluşturulan paratüberküloz’un Şanlıurfa’daki sığırlarda seroprevalansının belirlenmesi amaçlanmıştır. amaçla, tesadüfi örnekleme ile Şanlıurfa merkez ilçelerinden, sağlıklı 465 sığırdan alınan serumlar kullanıldı. Serum örneklerinden anti-MAP antikorları...

The activity of Rivaroxoban oxazolidinone series against Mycobacterium terrae was investigated in silico and vitro. In studies have shown a high binding affinity Rivaroxaban to β-ketoacyl[ACP]synthase I that plays key role the biosynthesis mycolic acids, being components mycobacterial cell wall. molecular docking study, two main sites with protein were predicted evaluated: minimum energies foun...

Tuberkulosis merupakan penyakit yang disebabkan oleh Mycobacterium tuberculosis menyerang organ paru. Adanya peradangan Tuberculosis didalam tubuh ditandai dengan respon inflamasi. Respon inflamasi dapat didiagnosa melalui pemeriksaan C Reactive Protein sebagai anti infeksi imun seseorang. Biasanya adanya peningkatan kadar mengindikasikan tidak terkontrol. Selain tersebut, penanda lainnya dilih...

Infections caused by nontuberculous mycobacteria (NTM) are increasing worldwide, resulting in a new global health concern. NTM treatment is complex and requires combinations of several drugs for lengthy periods. In spite this, disease often associated with poor outcomes. The anti-parasitic family macrocyclic lactones (ML) (divided two subfamilies: avermectins milbemycins) was previously describ...

The genus Mycobacterium comprises more than 150 species, including important pathogens for humans which cause major public health problems. The vast majority of efforts to understand the genus have been addressed in studies with Mycobacterium tuberculosis. The biological differentiation between M. tuberculosis and nontuberculous mycobacteria (NTM) is important because there are distinctions in ...