PURPOSE Over the last few decades, preferred epilepsy surgical approaches have developed from standard lobectomies to individually tailored resections. Yet, it remains uncertain how small surgical interventions can be without compromising the success of the surgery. Particularly in patients with epileptogenic lesions identified by magnetic resonance imaging (MRI), it is unresolved whether resec...

Patients with focal drug-resistant epilepsy are potential candidates for surgery. Stereo-electroencephalograph (SEEG) is often considered as the "gold standard" to identify the epileptogenic zone (EZ) that accounts for the onset and propagation of epileptiform discharges. However, visual analysis of SEEG still prevails in clinical practice. In addition, epilepsy is increasingly understood to be...

Focal cortical dysplasias (FCDs) are the most common cause of treatment-resistant epilepsy affecting pediatric population. Most individuals with FCD have seizure onset within first five years life and majority will develop by age sixteen. Many cases postulated to be result abnormal brain development in utero germline or somatic gene mutations regulating neuronal growth migration during corticog...

Corresponding Author: A. Gorji MD Institute of Physiology I, Münster Universität, Robert-Koch-Strasse 27a D-48149 Munster, Germany Tel: +49-251-8355564 Fax: +49-251-8355551 E-mail: [email protected] Abstract Objective This review summarizes some patterns of pre-surgical evaluation of epilepsy in children with medically refractory seizures. Epilepsy surgery is a valuable therapeutic option...

[(18)F]MPPF PET has previously been used to identify the epileptic lobe in temporal lobe epilepsy (TLE) patients at the group level. This study aims to validate the visual analysis of [(18)F]MPPF PET in the assessment of individual TLE patients for their suitability to undergo temporal lobe resection. Forty-two patients suffering from TLE and 18 control subjects matched for age and gender were ...

The relationship between the chemical structure and epileptogenic activity of quinolones was investigated. When the quinolones were administered intravenously to mice concomitantly with oral biphenylacetic acid, a major metabolite of the nonsteroidal antiinflammatory drug fenbufen, enoxacin, norfloxacin, ciprofloxacin, and pipemidic acid, which have an unsubstituted piperazine moiety at the 7 p...

INTRODUCTION Presurgical work-ups of patients with pharmacoresistant epileptic seizures can require multiple diagnostic methods if magnetic resonance imaging (MRI) combined with video-EEG monitoring fails to show an epileptogenic lesion. Yet, the added value of available methods is not clear. In particular, only a minority of epilepsy centres apply magnetoencephalography (MEG). This study explo...