fenugreek (trigonella foeum-graecum l.) has been used in iranian traditional medicine for treatment of different kinds of inflammation disorders. in the present study, anti- inflammatory activity of the methanolic extract of the plant (at doses of 100, 200 and 400 mg/kg) were studied using carrageenan-induced edema method and compared with the effects of dexamethasone and ibuprofen. various con...

Synthesis of novel 7-substituted isoellipticines and isoellipticinium salts is described, with optimisation of routes, representing a new class of anti-cancer agent. Initial assessment of biological activity using a topoisomerase II decatenation assay and NCI screening highlighted strong anti-cancer activity, further developed in a panel of isoellipticinium salts. Interestingly, low correlation...

Abstract: Background and Objectives: In nanotechnology, biosynthesis of nanoparticles has gained considerable attention. Development synthesis plant based metallic with improved properties less undesirable effects have many advantages over the conventional methods. addition to performing their intended function, these phyto antioxidant functionalized can protect against oxidative damage. Pergul...

Dichloroacetate (DCA) as a small, cheap and available anticancer agent, is a pyruvate mimetic compound that stimulates the activity of pyruvate dehydrogenase (PDH) enzyme through inhibition of pyruvate dehydrogenase kinases (PDHK1-4). DCA turns on programed cell death (apoptosis) which suppressed in tumor cells and therefore inhibits tumor growth. DCA also interferes with the glucose uses of ca...

There is a multitude of life-threatening and widespread health issues worldwide, regarding weak immunity, severe inflammation, viral infections, bacterial infections as well antimicrobial resistance (AMR), high free radicals generation, cancer. Ginger, perennial plant the Zingiberaceae family with several authentic nutritional medicinal values used in many countries traditional medicine. That w...