Neurodegeneration is a progressive and irreversible loss of neuronal cells in specific regions of the brain. Alzheimer Diseases (AD) Parkinson Disease (PD) are the most common forms of neurodegenerative diseases in older people. Exosomes are extracellular nanovesicles that have a key role in physiological processes such as intercellular communication, cell migration, angiogenesis, and anti-tumo...

BACKGROUND Dietary n-3 polyunsaturated fatty acids improve brain functioning in animal studies, but there is limited study of whether this type of fat protects against Alzheimer disease. OBJECTIVE To examine whether fish consumption and intake of different types of n-3 fatty acids protect against Alzheimer disease. DESIGN Prospective study conducted from 1993 through 2000, of a stratified r...

Ginger (Zingiber officinale), despite being a common dietary adjunct that contributes to the taste and flavor of foods, is well known to contain a number of potentially bioactive phytochemicals having valuable medicinal properties. Although recent studies have emphasized their benefits in Alzheimer's disease, limited information is available on the possible mechanism by which it renders anti-Al...

BACKGROUND Adenoviruses (Ads) cause continuous outbreaks of acute respiratory disease (ARD) in US military training facilities. In 1996, the loss of vaccines targeting the dominant recruit-associated serotypes precipitated the reemergence of Ads in these populations. Between 1999 and 2002, serotype 4 accounted for >95% of Ads isolated from recruits and for >50% of ARD cases in training faciliti...

Objective: This study aimed at investigating the effectiveness of cognitive-behavioral group therapy on guilt feeling among family caregivers of patients with Alzheimer’s disease. Methods: This research was a quasi-experimental study where in the pre-test and post-test control group design was employed. The statistical population of this study consisted of the female family caregivers of...

Non-steroidal anti-inflammatory drugs (NSAIDs) identified effective in many diseases. One of which is neurodegenerative diseases including Alzheimer disease (AD). In this study gross alteration of gene expression in AD mice by ibuprofen treatment is investigated via Protein-protein interaction network (PPI) analysis. Expression profiling of microarray dataset GSE67306 was retrieved from GEO dat...

PURPOSE To compare brain tissue in patients with Alzheimer disease with that in elderly control subjects by using high-resolution MR imaging and quantitative tissue-segmentation techniques. METHODS MR imaging of the brain was performed in 21 patients with Alzheimer disease and 17 control subjects. A computerized segmentation program was used to quantify volumes of ventricular and sulcal cereb...

introduction:brain imaging with f-18 fluorodeoxyglucose (18f-fdg) positron ‎emission tomography or tc-99m hexamethylpropyleneamine oxime (‎99mtc-hmpao) spect is widely used for the evaluation of alzheimer's ‎dementia (ad); we aim to assess superiority of one method over the ‎other. methods: twenty four patients with clinical diagnosis of alzheimer disease ‎underwent 18f-fdg pet and ‎99mtc-...

Objetivo: investigar a importância do enfermeiro no cuidado ao binômio demenciado(a)/cuidador(a) manejo Alzheimer. Método: revisão integrativa nas bases de dados DOAJ, Latindex, ROAD e Scielo Brazil, usando termos “Doença Alzheimer”, “enfermagem”, “cuidados enfermagem”, “assistência paciente”, “cuidadores” “familiar cuidador”. Pergunta norteadora: quais aspectos são ou devem ser considerados pe...

BACKGROUND The metabolic syndrome is a risk factor for cardiovascular diseases, which have been linked to Alzheimer disease. However, a link between Alzheimer disease and the metabolic syndrome has not yet been established. OBJECTIVE To investigate the relationship between the metabolic syndrome and Alzheimer disease. DESIGN, SETTING, AND PARTICIPANTS Case-control study of 50 consecutive pa...