Cyclooxygenase (Cox) is a key enzyme in the biosynthesis of prostaglandins and, as such, is the target of non-steroidal anti-inflammatory drugs (NSAIDs). Two isoforms exist, being expressed constitutively (Cox-1), or inducibly in response to inflammatory mediators (Cox-2). Currently available NSAIDs inhibit both isoforms somewhat equipotently but selective Cox-2 inhibition may eliminate unwante...

Exceptionally powerful anion receptors have been constructed by placing squaramide groups in axial positions on a steroidal framework. The steroid preorganizes the squaramide NH groups such that they can act cooperatively on a bound anion, while maintaining solubility in nonpolar media. The acidic NH groups confer higher affinities than previously-used ureas or thioureas. Binding constants exce...

Active learning methods which present selected examples from the corpus for annotation provide more efficient of supervised relation extraction models, but they leave developer in unenviable role a passive informant. To restore developer’s proper as partner with system, we must give an ability to inspect model during development. We propose make this possible through representation based...

Metalloporphyrins [Mn(III) and In(III)] are investigated as active polymer fihn components in the design of reversible anion-selective optical sensors. The optical measurements are made by casting thin plasticiied polymer films (PVC, polyurethane, etc.) containing the given metalloporphyrhts on glass plates. When bathed in aqueous test solutions, the optical response of such fihns is based upon...

Several recently reported techniques for the automatic acquisition of Information Extraction (IE) systems have used dependency trees as the basis of their extraction pattern representation. These approaches have used a variety of pattern models (schemes for representing IE patterns based on particular parts of the dependency analysis). An appropriate model should be expressive enough to represe...

Nickel(II) complexes of [14]tetraazaannulene derivatives incorporating aromatic rings into their azaannulene framework were synthesized, and the anion-selectivity of the [14]tetraazaannulene nickel complexes 1 - 4 was evaluated by potentiometric measurements with solvent polymeric membrane electrodes. All of the [14]Tetraazaannulene nickel complexes, except 3, were found to exhibit high selecti...

Three acylhydrazone-based compounds were designed as novel neutral sensors for anions, and synthesized by simple steps in good yields. Their anion recognition properties were studied by UV-vis and H-NMR spectroscopy. The results showed that the receptors 1, 2, and 3 all had a better selectivity for F− and CH3COO − , but no evident binding with Cl− , Br− , I− , NO3 , H2PO − 4 , or HSO − 4 . The ...

Supramolecular transmembrane anion transporters are promising therapeutics for channelopathies and typically operate via hydrogen bonding. Sigma-hole interactions including halogen bonding (XB), chalcogen (ChB), pnictogen (PnB) have emerged as alternatives in both transport activity selectivity. This forum highlights recent advances identifies properties unique to sigma-hole interactions.