نتایج جستجو برای: animal imaging
تعداد نتایج: 654685 فیلتر نتایج به سال:
There is a pressing need for novel diagnostic and progression biomarkers of neurodegeneration. However, the inability to determine disease duration stage in patients with Alzheimer’s (AD) hinders their discovery. Because animal models allow us circumvent some these limitations, they have proven be paramount importance clinical research. Due clear optics eye, retina combined optical coherence to...
UNLABELLED Localization of regions with increased uptake of radiotracer in small-animal SPECT is greatly facilitated when using coregistration with anatomic images of the same animal. As MRI has several advantages compared with CT (soft-tissue contrast and lack of ionizing radiation) we developed a SPECT/low-field MRI hybrid device for small-animal imaging. METHODS A small-animal single-pinho...
UNLABELLED Recent developments have established molecular imaging of mouse models with small-animal PET and bioluminescence imaging (BLI) as an important tool in cancer research. One of the disadvantages of these imaging modalities is the lack of anatomic information. We combined small-animal PET and BLI technology with small-animal CT to obtain fusion images with both molecular and anatomic in...
OBJECTIVE To describe the Single Photon Emission Microscope (SPEM), a state-of-the-art instrument for small animal SPECT imaging, and characterize its performance presenting typical images of different animal organs. METHODS SPEM consists of two independent imaging devices based on high resolution scintillators, high sensitivity and resolution Electron-Multiplying CCDs and multi-pinhole colli...
The process of drug discovery and development requires substantial resources and time. The drug industry has tried to reduce costs by conducting appropriate animal studies together with molecular biological and genetic analyses. Basic science research has been limited to in vitro studies of cellular processes and ex vivo tissue examination using suitable animal models of disease. However, in th...
UNLABELLED Small-animal imaging systems are often characterized using phantoms, which may not predict performance in clinical applications. An implantable synthetic SPECT lesion would facilitate characterization of lesion detectability in a living animal. METHODS Anion-exchange columns with bed volumes of 100-300 nL were constructed from medical-grade polyvinyl chloride tubing and resin. The ...
Molecular imaging offers new possibilities for pre-clinical (small animal) research, because it allows in-vivo imaging of biochemical (microscopic) processes at a macroscopic level. This means that the onset of pathological processes can be studied at an early stage, long before large-scale anatomical changes occur, and followed over time in the same animal. Nowadays a large range of small anim...
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