Angiogenesis is essential in development and wound healing and contributes to the pathogenesis of many diseases. The signalling pathways activated in angiogenesis are, in part ,known and the overall tyrosine phosphorylation of cellular proteins plays a relevant role. By RNA fingerprinting, we isolated a tyrosine phosphatase, HD-PTP, modulated in human endothelial cells exposed to human immunode...

The prototype members of the IL-1 gene family are well recognized for their inflammatory and angiogenic activities in IL-1α and IL-1β are initially synthesized as precursor proteins and, whereas IL-1α is processed to its mature form by calpain, IL-1β is processed by an aspartate-specific protease from the caspase family termed the IL-1β-converting enzyme (Kobayashi et al., 1990; Kostura et al.,...

Ischemic heart disease is the major underlying cause of myocardial infarction (MI), scarring, and hypertrophy that can progress to heart failure. Each year, ≈300 000 individuals have recurring MIs, which is projected to ≈40% of the US population in the next 15 years. More recently, angiogenic therapy for myocardial ischemia has received significant attention. These therapeutic angiogenic strate...

background: mesenchymal stem cells (mscs) are recently introduced as novel immunological gene carriers for treatment of cancer. it is believed that balance between the expression of angiogenic and anti-angiogenic factors, such as sdf-1 and ip-10, may regulate neovascularization within the tumor. methods: in this study, we compared the expression of important tumor promoting mediators in ip-10-t...

In adult bone marrow, mature erythroblasts are produced within structures called erythroblastic islands and then cross the endothelial barrier to reach circulation. Erythroblastic islands are composed of a central macrophage surrounded by maturing erythroblasts. In this study, it is shown that erythroid cells, but not the other mature hematopoietic cells, coexpress 2 angiogenic factors, vascula...

Angiogenesis is implicated in diverse pathological conditions such as cancer, rheumatoid arthritis, psoriasis, atherosclerosis, and retinal neovascularization. In the present study, we investigated the effects of modified rice bran hemicellulose (MRBH), a water-soluble hemicellulose preparation from rice bran treated with shiitake enzymes, on vascular endothelial growth factor (VEGF)-induced an...

The role of angiogenic molecules, like vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF) in tumor angiogenesis was well confirmed. Photodynamic therapy (PDT) action is, to very high degree, based on tumor vasculature damage. Therefore, it seemed to be important to evaluate growth factor receptors after PDT. The extent of receptor expression was studied by immuno-histo...

METHODS. HRMP and HREC phenotypes were verified by growth factor stimulation of intracellular calcium–ion mobilization. Glucocorticoid receptor phosphorylation was assessed with an anti-phospho-Ser glucocorticoid receptor antibody. Secretion of 89 inflammatory and angiogenic proteins were compared in cells incubated with (1) normal (5 mM) or high (25 mM) D-glucose and (2) control medium, TNF(10...